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Peroxisomal Membrane Protein 4 (PXMP4)

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PMP24; Peroxisomal Membrane Protein 24kDa; 24 kDa peroxisomal intrinsic membrane protein

Peroxisomal Membrane Protein 4 (PXMP4)
CCC Q488
HGNC 15920
MGI 1891701
PubMed 17041235
RGD 628782
UniProt Q9Y6I8
Wiki PXMP4
Pxmp4, which encodes a 24-kDa peroxisomal integral membrane protein of unknown function. Pxmp4 was originally isolated as a 24-kDa polypeptide from rat liver peroxisome membranes (36). As increased message for Pxmp4 is associated with the NOD allele that confers weaker NKT cell stimulatory capacity, one possibility is that Pxmp4 contributes to the biosynthesis of a nonstimulatory etherphospholipid ligand for CD1d. Pxmp4 may be a component in a fatty acid degradation pathway that catabolizes stimulatory CD1d ligands. Peroxisomes play a critical role in the - and -oxidation of very long chain fatty acids. Pex19 associates with Pxmp4 during or immediately after its translation by free ribosomes. Peroxisomal membrane insertion of the Pxmp4-Pex19 complex is dependent on Pex3p.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Peroxisomal Membrane Protein 4 (PXMP4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Peroxisomal Membrane Protein 4 (PXMP4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Peroxisomal Membrane Protein 4 (PXMP4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Peroxisomal Membrane Protein 4 (PXMP4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Peroxisomal Membrane Protein 4 (PXMP4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Peroxisomal Membrane Protein 4 (PXMP4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Peroxisomal Membrane Protein 4 (PXMP4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Peroxisomal Membrane Protein 4 (PXMP4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Peroxisomal Membrane Protein 4 (PXMP4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Peroxisomal Membrane Protein 4 (PXMP4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Peroxisomal Membrane Protein 4 (PXMP4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Peroxisomal Membrane Protein 4 (PXMP4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Peroxisomal Membrane Protein 4 (PXMP4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Peroxisomal Membrane Protein 4 (PXMP4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Peroxisomal Membrane Protein 4 (PXMP4) ELISA Kit Customized Service Offer
  1. "Identification of a 24 kDa intrinsic membrane protein from mammalian peroxisomes."Biochim. Biophys. Acta 1445:337-341(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis."J. Cell Biol. 148:931-944(2000) [PubMed] [Europe PMC] [Abstract]
  7. "PEX19 is a predominantly cytosolic chaperone and import receptor for class 1 peroxisomal membrane proteins."J. Cell Biol. 164:57-67(2004) [PubMed] [Europe PMC] [Abstract]
  8. "PMP24, a gene identified by MSRF, undergoes DNA hypermethylation-associated gene silencing during cancer progression in an LNCaP model."Oncogene 23:250-259(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Methylation of a single intronic CpG mediates expression silencing of the PMP24 gene in prostate cancer."Prostate 70:765-776(2010) [PubMed] [Europe PMC] [Abstract]