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Sorting Nexin 10 (SNX10)

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Sorting Nexin 10 (SNX10)
CCC Q446
HGNC 14974
MGI 1919232
PubMed 22174188
RGD 1305782
UniProt Q9Y5X0
SNX10 encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. This gene encodes a protein whose function has not been determined.
Eukaryotic cells maintain a sophisticated network of intracellular membranous system to ensure the proper distribution and compartmentalization of cellular proteins critical for diverse functions such as cell division or cell-cell communication. Yet, little is known about the mechanism that regulates the homeostasis of this system. SNX10 activity may be involved in the regulation of endosome homeostasis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sorting Nexin 10 (SNX10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sorting Nexin 10 (SNX10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sorting Nexin 10 (SNX10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sorting Nexin 10 (SNX10) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sorting Nexin 10 (SNX10) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sorting Nexin 10 (SNX10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sorting Nexin 10 (SNX10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sorting Nexin 10 (SNX10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sorting Nexin 10 (SNX10) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sorting Nexin 10 (SNX10) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sorting Nexin 10 (SNX10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sorting Nexin 10 (SNX10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sorting Nexin 10 (SNX10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sorting Nexin 10 (SNX10) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sorting Nexin 10 (SNX10) ELISA Kit Customized Service Offer
  1. "A large family of endosome-localized proteins related to sorting nexin 1."Biochem. J. 358:7-16(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Human chromosome 7: DNA sequence and biology." Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Sorting nexin 10 induces giant vacuoles in mammalian cells."J. Biol. Chem. 281:36891-36896(2006) [PubMed] [Europe PMC] [Abstract]
  7. "A SNX10/V-ATPase pathway regulates ciliogenesis in vitro and in vivo."Cell Res. 22:333-345(2012) [PubMed] [Europe PMC] [Abstract]
  8. "SNX10 is required for osteoclast formation and resorption activity."J. Cell. Biochem. 113:1608-1615(2012) [PubMed] [Europe PMC] [Abstract]
  9. "Homozygous stop mutation in the SNX10 gene in a consanguineous Iraqi boy with osteopetrosis and corpus callosum hypoplasia."Eur. J. Med. Genet. 56:32-35(2013) [PubMed] [Europe PMC] [Abstract]
  10. "An SNX10 mutation causes malignant osteopetrosis of infancy."J. Med. Genet. 49:221-226(2012) [PubMed] [Europe PMC] [Abstract]
  11. "SNX10 mutations define a subgroup of human autosomal recessive osteopetrosis with variable clinical severity." J. Bone Miner. Res. 28:1041-1049(2013) [PubMed] [Europe PMC] [Abstract]