![DnaJ/HSP40 Homolog Subfamily A, Member 4 (DNAJA4)](/upload/item/img/DnaJ-HSP40-Homolog-Subfamily-A--Member-4-(DNAJA4)-84440.jpg)
DnaJA4 is a SREBP-regulated chaperone involved in the cholesterol biosynthesis pathway. DnaJA4, as a new SREBP-responsive gene. DnaJA4 was overexpressed in COS cells, which induced a specific increase in the synthesis of cholesterol from acetate. DnaJA4 overexpression increased the activity and the protein content of HMG-CoA reductase, the rate limiting enzyme in this pathway. At the molecular level, DnaJA4 overexpression did not alter HMG-CoA reductase stability or mRNA levels, suggesting a co-translational effect of the chaperone. In the DnaJ/Hsp40 family, DnaJA4 uniquely exhibited SREBP-regulated expression, and also responded to heat shock. Through its responsiveness to SREBP, and its stimulatory effect on cholesterol synthesis, the DnaJA4 chaperone can be viewed as a new player in cholesterol synthesis.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant DnaJ/HSP40 Homolog Subfamily A, Member 4 (DNAJA4) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to DnaJ/HSP40 Homolog Subfamily A, Member 4 (DNAJA4) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to DnaJ/HSP40 Homolog Subfamily A, Member 4 (DNAJA4) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for DnaJ/HSP40 Homolog Subfamily A, Member 4 (DNAJA4) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for DnaJ/HSP40 Homolog Subfamily A, Member 4 (DNAJA4) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant DnaJ/HSP40 Homolog Subfamily A, Member 4 (DNAJA4) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to DnaJ/HSP40 Homolog Subfamily A, Member 4 (DNAJA4) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to DnaJ/HSP40 Homolog Subfamily A, Member 4 (DNAJA4) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for DnaJ/HSP40 Homolog Subfamily A, Member 4 (DNAJA4) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for DnaJ/HSP40 Homolog Subfamily A, Member 4 (DNAJA4) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant DnaJ/HSP40 Homolog Subfamily A, Member 4 (DNAJA4) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to DnaJ/HSP40 Homolog Subfamily A, Member 4 (DNAJA4) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to DnaJ/HSP40 Homolog Subfamily A, Member 4 (DNAJA4) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for DnaJ/HSP40 Homolog Subfamily A, Member 4 (DNAJA4) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for DnaJ/HSP40 Homolog Subfamily A, Member 4 (DNAJA4) | ELISA Kit Customized Service Offer |
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