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Bromodomain Containing Protein 7 (BRD7)

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CELTIX1; BP75; 75 kDa bromodomain protein

Bromodomain Containing Protein 7 (BRD7)
CCC Q414
HGNC 14310
MGI 1349766
PubMed 18809673
RGD 1309891
UniProt Q9NPI1
Wiki BRD7
BRD7 is a member of the bromodomain-containing protein family. The product of this gene has been identified as a component of one form of the SWI/SNF chromatin remodeling complex, and as a protein which interacts with p53 and is required for p53-dependent oncogene-induced senescence which prevents tumor growth. Pseudogenes have been described on chromosomes 2, 3, 6, 13 and 14. Alternative splicing results in multiple transcript variants. BRD7 as a novel component of the Polybromo-associated BRG1-associated factor (PBAF) complex in both ESCs and differentiated cells.Knockdown studies of PBAF-specific BRD7 and of a signature subunit within the BAF complex, ARID1A, showed that these two subcomplexes affect SWI/SNF target genes differentially, in some cases even antagonistically.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Bromodomain Containing Protein 7 (BRD7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Bromodomain Containing Protein 7 (BRD7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Bromodomain Containing Protein 7 (BRD7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Bromodomain Containing Protein 7 (BRD7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Bromodomain Containing Protein 7 (BRD7) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Bromodomain Containing Protein 7 (BRD7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Bromodomain Containing Protein 7 (BRD7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Bromodomain Containing Protein 7 (BRD7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Bromodomain Containing Protein 7 (BRD7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Bromodomain Containing Protein 7 (BRD7) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Bromodomain Containing Protein 7 (BRD7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Bromodomain Containing Protein 7 (BRD7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Bromodomain Containing Protein 7 (BRD7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Bromodomain Containing Protein 7 (BRD7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Bromodomain Containing Protein 7 (BRD7) ELISA Kit Customized Service Offer
  1. "Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2."J. Cell. Physiol. 185:269-279(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Regulation of transcription by the heterogeneous nuclear ribonucleoprotein E1B-AP5 is mediated by complex formation with the novel bromodomain-containing protein BRD7."Biochem. J. 371:385-393(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The transcriptional regulation role of BRD7 by binding to acetylated histone through bromodomain."J. Cell. Biochem. 97:882-892(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Identification of nuclear localization signal that governs nuclear import of BRD7 and its essential roles in inhibiting cell cycle progression."J. Cell. Biochem. 98:920-930(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
  10. "BRD7, a subunit of SWI/SNF complexes, binds directly to BRCA1 and regulates BRCA1-dependent transcription."Cancer Res. 70:2538-2547(2010) [PubMed] [Europe PMC] [Abstract]
  11. "BRD7 is a candidate tumour suppressor gene required for p53 function."Nat. Cell Biol. 12:380-389(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence."Proc. Natl. Acad. Sci. U.S.A. 107:14280-14285(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  16. "Solution structure of BRD7 bromodomain and its interaction with acetylated peptides from histone H3 and H4."Biochem. Biophys. Res. Commun. 358:435-441(2007) [PubMed] [Europe PMC] [Abstract]