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Sad-1 And Unc-84 Domain Containing Protein 2 (SUN2)

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UNC84B; FRIGG; RAB5IP; SUN domain-containing protein 2; Protein unc-84 homolog B; Rab5-interacting protein; Sad1/unc-84 protein-like 2

Sad-1 And Unc-84 Domain Containing Protein 2 (SUN2)
CCC Q407
HGNC 14210
MGI 2443011
PubMed 20551905
RGD 1563141
UniProt Q9UH99
SUN2 protein contains an N-terminal signal sequence, followed by 2 coiled-coil domains, 2 transmembrane domains, and a C-terminal SUN domain. Immunofluorescence microscopy demonstrated nuclear rim-like expression of epitope-tagged or endogenous SUN2 in HeLa cells. This localization was dependent on amino acids 26 to 339 of SUN2. Immunoblot and biochemical analyses showed expression of an 85-kD SUN2 protein. Further analyses revealed that SUN2 is a type II transmembrane protein with the SUN domain protruding in the periplasmic space between the INM and the ONM. The predicted proteins contain 824 and 724 amino acids, respectively, and their C termini share homology with the C termini of C. elegans Unc84 and S. pombe Sad1. Both SUN1 and SUN2 contain a transmembrane region.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sad-1 And Unc-84 Domain Containing Protein 2 (SUN2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sad-1 And Unc-84 Domain Containing Protein 2 (SUN2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sad-1 And Unc-84 Domain Containing Protein 2 (SUN2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sad-1 And Unc-84 Domain Containing Protein 2 (SUN2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sad-1 And Unc-84 Domain Containing Protein 2 (SUN2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sad-1 And Unc-84 Domain Containing Protein 2 (SUN2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sad-1 And Unc-84 Domain Containing Protein 2 (SUN2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sad-1 And Unc-84 Domain Containing Protein 2 (SUN2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sad-1 And Unc-84 Domain Containing Protein 2 (SUN2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sad-1 And Unc-84 Domain Containing Protein 2 (SUN2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sad-1 And Unc-84 Domain Containing Protein 2 (SUN2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sad-1 And Unc-84 Domain Containing Protein 2 (SUN2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sad-1 And Unc-84 Domain Containing Protein 2 (SUN2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sad-1 And Unc-84 Domain Containing Protein 2 (SUN2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sad-1 And Unc-84 Domain Containing Protein 2 (SUN2) ELISA Kit Customized Service Offer
  1. "A novel membrane-anchored Rab5 interacting protein required for homotypic endosome fusion."J. Biol. Chem. 275:24661-24669(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization of the structures involved in localization of the SUN proteins to the nuclear envelope and the centrosome."DNA Cell Biol. 25:554-562(2006) [PubMed] [Europe PMC] [Abstract]
  3. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
  4. "A genome annotation-driven approach to cloning the human ORFeome."Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "UNC-84 localizes to the nuclear envelope and is required for nuclear migration and anchoring during C. elegans development."Development 126:3171-3181(1999) [PubMed] [Europe PMC] [Abstract]
  9. "Isolation of differentially expressed genes in human heart tissues."Biochim. Biophys. Acta 1588:241-246(2002) [PubMed] [Europe PMC] [Abstract]
  10. "A mass spectrometry-based proteomic approach for identification of serine/threonine-phosphorylated proteins by enrichment with phospho-specific antibodies: identification of a novel protein, Frigg, as a protein kinase A substrate."Mol. Cell. Proteomics 1:517-527(2002) [PubMed] [Europe PMC] [Abstract]
  11. "Nuclear membrane proteins with potential disease links found by subtractive proteomics."Science 301:1380-1382(2003) [PubMed] [Europe PMC] [Abstract]
  12. "Sun2 is a novel mammalian inner nuclear membrane protein."J. Biol. Chem. 279:25805-25812(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  14. "Functional association of Sun1 with nuclear pore complexes."J. Cell Biol. 178:785-798(2007) [PubMed] [Europe PMC] [Abstract]
  15. "Sun1 forms immobile macromolecular assemblies at the nuclear envelope."Biochim. Biophys. Acta 1783:2415-2426(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness."Exp. Cell Res. 314:1892-1905(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  19. "TMEM43 mutations in Emery-Dreifuss muscular dystrophy-related myopathy."Ann. Neurol. 69:1005-1013(2011) [PubMed] [Europe PMC] [Abstract]
  20. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  21. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]