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Prune Homolog (PRUNE)

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DRES-17; HTCD37; Drosophila-related expressed sequence 17

Prune Homolog (PRUNE)
CCC Q381
HGNC 13420
MGI 1925152
PubMed 23249412
RGD 1359521
UniProt Q86TP1
PRUNE, the human homologue of the Drosophila gene, is located in 1q21.3, a region highly amplified in human sarcomas, malignant tumours of mesenchymal origin. Prune protein interacts with the metastasis suppressor nm23-H1, but shows impaired affinity towards the nm23-H1 S120G mutant associated with advanced neuroblastoma.
Prune may act as a negative regulator of nm23-H1 activity. PRUNE amplification was generally accompanied by high mRNA and moderate to high protein levels. The sarcoma samples expressed nm23-H1 mostly at low or moderate levels, whereas mRNA and protein levels were moderate to high in breast carcinomas. For the more aggressive sarcoma subtypes, 9/13 patients with PRUNE amplification developed metastases.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Prune Homolog (PRUNE) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Prune Homolog (PRUNE) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Prune Homolog (PRUNE) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Prune Homolog (PRUNE) CLIA Kit Customized Service Offer
n/a ELISA Kit for Prune Homolog (PRUNE) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Prune Homolog (PRUNE) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Prune Homolog (PRUNE) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Prune Homolog (PRUNE) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Prune Homolog (PRUNE) CLIA Kit Customized Service Offer
n/a ELISA Kit for Prune Homolog (PRUNE) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Prune Homolog (PRUNE) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Prune Homolog (PRUNE) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Prune Homolog (PRUNE) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Prune Homolog (PRUNE) CLIA Kit Customized Service Offer
n/a ELISA Kit for Prune Homolog (PRUNE) ELISA Kit Customized Service Offer
  1. "Evidence for interaction between human PRUNE and nm23-H1 NDPKinase."Oncogene 18:7244-7252(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Sequencing analysis of forty-eight human image cDNA clones similar to Drosophila mutant protein."DNA Seq. 9:307-315(1998) [PubMed] [Europe PMC] [Abstract]
  6. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Amplification and overexpression of PRUNE in human sarcomas and breast carcinomas-a possible mechanism for altering the nm23-H1 activity." Oncogene 20:6881-6890(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Prune cAMP phosphodiesterase binds nm23-H1 and promotes cancer metastasis."Cancer Cell 5:137-149(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Overexpression of h-prune in breast cancer is correlated with advanced disease status."Clin. Cancer Res. 11:199-205(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Glycogen synthase kinase 3 and h-prune regulate cell migration by modulating focal adhesions."Mol. Cell. Biol. 26:898-911(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Domain mapping on the human metastasis regulator protein h-Prune reveals a C-terminal dimerization domain."Biochem. J. 407:199-205(2007) [PubMed] [Europe PMC] [Abstract]
  12. "Phosphorylation of nm23-H1 by CKI induces its complex formation with h-prune and promotes cell motility."Oncogene 27:1853-1864(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]