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ERO1 Like Protein (ERO1L)

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ERO1A; ERO1-alpha; ERO1-like; Endoplasmic Reticulum Oxidoreductin 1 Like Protein; Oxidoreductin-1-L-alpha

ERO1 Like Protein (ERO1L)
CCC Q375
HGNC 13280
MGI 1354385
PubMed 18809725
RGD 621713
UniProt Q96HE7
Wiki ERO1L
ERO1-L shares extensive homology with the Saccharomyces cerevisiae ERO1 gene, required in yeast for oxidative protein folding. When expressed in mammalian cells, the product of the human ERO1-L gene co-localizes with ER markers and displays Endo-H-sensitive glycans. In isolated microsomes, ERO1-L behaves as a type II integral membrane protein.
ERO1-L is able to complement several phenotypic traits of the yeast thermosensitive mutant ero1-1, including temperature and dithiothreitol sensitivity, and intrachain disulfide bond formation in carboxypeptidase Y. ERO1-L is no longer functional when either one of the highly conserved Cys-394 or Cys-397 is mutated. These results strongly suggest that ERO1-L is involved in oxidative ER protein folding in mammalian cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ERO1 Like Protein (ERO1L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ERO1 Like Protein (ERO1L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ERO1 Like Protein (ERO1L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ERO1 Like Protein (ERO1L) CLIA Kit Customized Service Offer
n/a ELISA Kit for ERO1 Like Protein (ERO1L) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ERO1 Like Protein (ERO1L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ERO1 Like Protein (ERO1L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ERO1 Like Protein (ERO1L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ERO1 Like Protein (ERO1L) CLIA Kit Customized Service Offer
n/a ELISA Kit for ERO1 Like Protein (ERO1L) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ERO1 Like Protein (ERO1L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ERO1 Like Protein (ERO1L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ERO1 Like Protein (ERO1L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ERO1 Like Protein (ERO1L) CLIA Kit Customized Service Offer
n/a ELISA Kit for ERO1 Like Protein (ERO1L) ELISA Kit Customized Service Offer
  1. "ERO1-L, a human protein that favors disulfide bond formation in the endoplasmic reticulum."J. Biol. Chem. 275:4827-4833(2000) [PubMed] [Europe PMC] [Abstract]
  2. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The C-terminal domain of yeast Ero1p mediates membrane localization and is essential for function."FEBS Lett. 508:117-120(2001) [PubMed] [Europe PMC] [Abstract]
  7. "ERp44, a novel endoplasmic reticulum folding assistant of the thioredoxin family."EMBO J. 21:835-844(2002) [PubMed] [Europe PMC] [Abstract]
  8. "The CXXCXXC motif determines the folding, structure and stability of human Ero1-Lalpha."EMBO J. 19:4493-4502(2000) [PubMed] [Europe PMC] [Abstract]
  9. "Endoplasmic reticulum oxidoreductin 1-lbeta (ERO1-Lbeta), a human gene induced in the course of the unfolded protein response."J. Biol. Chem. 275:23685-23692(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Manipulation of oxidative protein folding and PDI redox state in mammalian cells."EMBO J. 20:6288-6296(2001) [PubMed] [Europe PMC] [Abstract]
  11. "Unfolded cholera toxin is transferred to the ER membrane and released from protein disulfide isomerase upon oxidation by Ero1."J. Cell Biol. 159:207-216(2002) [PubMed] [Europe PMC] [Abstract]
  12. "The cellular oxygen tension regulates expression of the endoplasmic oxidoreductase ERO1-Lalpha."Eur. J. Biochem. 270:2228-2235(2003) [PubMed] [Europe PMC] [Abstract]
  13. "Thiol-mediated protein retention in the endoplasmic reticulum: the role of ERp44."EMBO J. 22:5015-5022(2003) [PubMed] [Europe PMC] [Abstract]
  14. "Two conserved cysteine triads in human Ero1alpha cooperate forefficient disulfide bond formation in the ER."J. Biol. Chem. 279:30047-30052(2004) [PubMed] [Europe PMC] [Abstract]
  15. "Glutathione limits Ero1-dependent oxidation in the endoplasmic reticulum."J. Biol. Chem. 279:32667-32673(2004) [PubMed] [Europe PMC] [Abstract]
  16. "PDILT, a divergent testis-specific protein disulfide isomerase with a non-classical SXXC motif that engages in disulfide-dependent interactions in the endoplasmic reticulum."J. Biol. Chem. 280:1376-1383(2005) [PubMed] [Europe PMC] [Abstract]
  17. "A novel disulphide switch mechanism in Ero1alpha balances ER oxidation in human cells."EMBO J. 27:2977-2987(2008) [PubMed] [Europe PMC] [Abstract]
  18. "Low reduction potential of Ero1alpha regulatory disulphides ensures tight control of substrate oxidation."EMBO J. 27:2988-2997(2008) [PubMed] [Europe PMC] [Abstract]
  19. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  21. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  22. "The endoplasmic reticulum sulfhydryl oxidase Ero1beta drives efficient oxidative protein folding with loose regulation."Biochem. J. 434:113-121(2011) [PubMed] [Europe PMC] [Abstract]
  23. "Hyperactivity of the Ero1alpha oxidase elicits endoplasmic reticulum stress but no broad antioxidant response."J. Biol. Chem. 287:39513-39523(2012) [PubMed] [Europe PMC] [Abstract]
  24. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  25. "Crystal structures of human Ero1alpha reveal the mechanisms of regulated and targeted oxidation of PDI."EMBO J. 29:3330-3343(2010) [PubMed] [Europe PMC] [Abstract]