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Zinc Finger, MYM-Type Protein 4 (ZMYM4)

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ZNF262; CDIR; Cell Death-Inhibiting RNA; Zinc finger protein 262

Zinc Finger, MYM-Type Protein 4 (ZMYM4)
CCC Q367
HGNC 13055
MGI 1915035
UniProt Q5VZL5
Domain analysis revealed that only full-length CDIR, and not its isolated 3-prime or 5-prime ends or ORF, confers resistance to cell killing. Mutation analysis revealed that the U-rich motifs AUUUUC and UUUCAUUUU are required for this protection. Resistance to cell killing was accompanied by elevated levels of p21 (CDKN1A) and BCL2 mRNA and protein. In vitro RNA-protein binding assays and Western blot analysis revealed that HSP27 (HSPB1) and all isoforms of AUF1 (HNRNPD) are components of a protein complex that binds CDIR. Use of recombinant proteins revealed that AUF1, but not HSP27, directly bound CDIR. Transfection of HeLa cells with another AUF1 target, the 3-prime UTR of MYC, also inhibited interferon-gamma-induced cell killing, but in a limited manner.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger, MYM-Type Protein 4 (ZMYM4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger, MYM-Type Protein 4 (ZMYM4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger, MYM-Type Protein 4 (ZMYM4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger, MYM-Type Protein 4 (ZMYM4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger, MYM-Type Protein 4 (ZMYM4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger, MYM-Type Protein 4 (ZMYM4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger, MYM-Type Protein 4 (ZMYM4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger, MYM-Type Protein 4 (ZMYM4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger, MYM-Type Protein 4 (ZMYM4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger, MYM-Type Protein 4 (ZMYM4) ELISA Kit Customized Service Offer
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