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Ubiquitin Specific Peptidase 20 (USP20)

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LSFR3A; VDU2; Ubiquitin Carboxyl-Terminal Hydrolase 20; Deubiquitinating enzyme 20; Ubiquitin thioesterase 20; VHL-interacting deubiquitinating enzyme 2

Ubiquitin Specific Peptidase 20 (USP20)
CCC Q357
HGNC 12619
MGI 1921520
PubMed 19424180
RGD 1305621
UniProt Q9Y2K6
Wiki USP20
The de-ubiquitinating enzymes USP33 and USP20 are recruited to the β2AR complexes, by using cellular co-immunoprecipitation assays. USP33 and USP20 could function to reverse β2AR ubiquitination and thus, could be involved in the regulation of receptor trafficking. Indeed, coexpression of the β2AR with USP33 or USP20 (USP33/20) results in a dramatic reduction of isoproterenol-stimulated ubiquitination of the receptor.
In contrast, similar coexpression of catalytically inactive USP33/20 mutants, which retains receptor binding, does not lead to any decrease in receptor ubiquitination. When HEK-293 cells expressing the β2AR are exposed to 10 μm isoproterenol for 6h, internalized β2ARs are found to colocalize with the lysosomal marker protein, LAMP2.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Specific Peptidase 20 (USP20) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Specific Peptidase 20 (USP20) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Specific Peptidase 20 (USP20) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Specific Peptidase 20 (USP20) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Specific Peptidase 20 (USP20) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Specific Peptidase 20 (USP20) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Specific Peptidase 20 (USP20) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Specific Peptidase 20 (USP20) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Specific Peptidase 20 (USP20) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Specific Peptidase 20 (USP20) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Specific Peptidase 20 (USP20) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Specific Peptidase 20 (USP20) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Specific Peptidase 20 (USP20) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Specific Peptidase 20 (USP20) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Specific Peptidase 20 (USP20) ELISA Kit Customized Service Offer
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  3. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
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  6. "Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation."J. Clin. Invest. 112:189-196(2003) [PubMed] [Europe PMC] [Abstract]
  7. "VHL protein-interacting deubiquitinating enzyme 2 deubiquitinates and stabilizes HIF-1alpha."EMBO Rep. 6:373-378(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization."EMBO J. 28:1684-1696(2009) [PubMed] [Europe PMC] [Abstract]
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  13. "USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110."Nature 495:255-259(2013) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]