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Pellino Homolog 2 (PELI2)

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Pellino-2; E3 ubiquitin-protein ligase pellino homolog 2

Pellino Homolog 2 (PELI2)
CCC Q307
HGNC 8828
MGI 1891445
PubMed 11306823
RGD 1565884
UniProt Q9HAT8
Wiki PELI2
Assignment of homologous genes, Peli1/PELI1 and Peli2/PELI2, for the Pelle adaptor protein Pellino to mouse chromosomes 11 and 14 and human chromosomes 2p13.3 and 14q21, respectively, by physical and radiation hybrid mapping. human Pellino2 as an interaction partner of IRAK4. Pellino 2 interacts with kinase-active as well as kinase-inactive IRAK1 and IRAK4. Furthermore, Pellino2 is one of the first substrates identified for IRAK1 and IRAK4. Functional studies using overexpression or RNAi knock-down of Pellino2 suggest a role of Pellino2 as a scaffolding protein similar to Pellino1. However, unlike Pellino1, Pellino2 does not seem to activate a specific transcription factor, but links TIR signaling to basic cellular processes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pellino Homolog 2 (PELI2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pellino Homolog 2 (PELI2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pellino Homolog 2 (PELI2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pellino Homolog 2 (PELI2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pellino Homolog 2 (PELI2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pellino Homolog 2 (PELI2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pellino Homolog 2 (PELI2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pellino Homolog 2 (PELI2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pellino Homolog 2 (PELI2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pellino Homolog 2 (PELI2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pellino Homolog 2 (PELI2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pellino Homolog 2 (PELI2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pellino Homolog 2 (PELI2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pellino Homolog 2 (PELI2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pellino Homolog 2 (PELI2) ELISA Kit Customized Service Offer
  1. "Assignment of homologous genes, Peli1/PELI1 and Peli2/PELI2, for the Pelle adaptor protein Pellino to mouse chromosomes 11 and 14 and human chromosomes 2p13.3 and 14q21, respectively, by physical and radiation hybrid mapping."Cytogenet. Cell Genet. 92:172-174(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Pellino2 activates the mitogen activated protein kinase pathway."FEBS Lett. 545:199-202(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Characterization of Pellino2, a substrate of IRAK1 and IRAK4."FEBS Lett. 547:157-161(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Kinase-active interleukin-1 receptor-associated kinases promote polyubiquitination and degradation of the Pellino family: direct evidence for PELLINO proteins being ubiquitin-protein isopeptide ligases."J. Biol. Chem. 282:29729-29737(2007) [PubMed] [Europe PMC] [Abstract]
  7. "The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1."Biochem. J. 409:43-52(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Pellino 2 is critical for Toll-like receptor/interleukin-1 receptor (TLR/IL-1R)-mediated post-transcriptional control."J. Biol. Chem. 287:25686-25695(2012) [PubMed] [Europe PMC] [Abstract]
  9. "Pellino proteins contain a cryptic FHA domain that mediates interaction with phosphorylated IRAK1."Structure 16:1806-1816(2008) [PubMed] [Europe PMC] [Abstract]