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MCF2 Cell Line Derived Transforming Sequence Protein (MCF2)

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DBL; ARHGEF21; Proto-oncogene DBL; Proto-oncogene MCF-2

MCF2 Cell Line Derived Transforming Sequence Protein (MCF2)
CCC Q296
HGNC 6940
MGI 96932
PubMed 1611909
RGD 1566098
UniProt P10911
Wiki MCF2
MCF2 is a member of a large family of GDP-GTP exchange factors that modulate the activity of small GTPases of the Rho family. Five-prime recombinations result in the loss of N-terminal codons, producing MCF2 variants with oncogenic potential.MCF2 is the designation of a transforming sequence identified using cotransfection of DNA from a human mammary carcinoma cell line.A comparison of the restriction maps of the DBL and MCF2 oncogenes, together with their chromosomal localization, indicates that they represent the same genetic locus. The DBL oncogene was initially detected as a transforming gene from a human diffuse B-cell lymphoma and was isolated as a 45-kb transforming human DNA sequence by cosmid cloning.MCF2 gene contains 25 exons and spans 85 kb.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MCF2 Cell Line Derived Transforming Sequence Protein (MCF2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MCF2 Cell Line Derived Transforming Sequence Protein (MCF2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MCF2 Cell Line Derived Transforming Sequence Protein (MCF2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MCF2 Cell Line Derived Transforming Sequence Protein (MCF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for MCF2 Cell Line Derived Transforming Sequence Protein (MCF2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MCF2 Cell Line Derived Transforming Sequence Protein (MCF2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MCF2 Cell Line Derived Transforming Sequence Protein (MCF2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MCF2 Cell Line Derived Transforming Sequence Protein (MCF2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MCF2 Cell Line Derived Transforming Sequence Protein (MCF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for MCF2 Cell Line Derived Transforming Sequence Protein (MCF2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MCF2 Cell Line Derived Transforming Sequence Protein (MCF2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MCF2 Cell Line Derived Transforming Sequence Protein (MCF2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MCF2 Cell Line Derived Transforming Sequence Protein (MCF2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MCF2 Cell Line Derived Transforming Sequence Protein (MCF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for MCF2 Cell Line Derived Transforming Sequence Protein (MCF2) ELISA Kit Customized Service Offer
  1. "Molecular cloning and characterization of the human dbl proto-oncogene: evidence that its overexpression is sufficient to transform NIH/3T3 cells."EMBO J. 7:2465-2473(1988) [PubMed] [Europe PMC] [Abstract]
  2. "Alternative splicing variants of the human DBL (MCF-2) proto-oncogene."Biochem. Biophys. Res. Commun. 299:455-458(2002) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The predicted DBL oncogene product defines a distinct class of transforming proteins."Proc. Natl. Acad. Sci. U.S.A. 85:2061-2065(1988) [PubMed] [Europe PMC] [Abstract]
  6. "Activation of a mcf.2 oncogene by deletion of amino-terminal coding sequences."Oncogene 3:709-715(1988) [PubMed] [Europe PMC] [Abstract]
  7. "A region of proto-dbl essential for its transforming activity shows sequence similarity to a yeast cell cycle gene, CDC24, and the human breakpoint cluster gene, bcr."New Biol. 3:372-379(1991) [PubMed] [Europe PMC] [Abstract]
  8. "Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product."J. Biol. Chem. 269:62-65(1994) [PubMed] [Europe PMC] [Abstract]
  9. "Activation of the guanine nucleotide exchange factor Dbl following ACK1-dependent tyrosine phosphorylation."Biochem. Biophys. Res. Commun. 268:141-147(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Role of the Sec14-like domain of Dbl family exchange factors in the regulation of Rho family GTPases in different subcellular sites."Cell. Signal. 16:899-906(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Ccpg1, a novel scaffold protein that regulates the activity of the Rho guanine nucleotide exchange factor Dbs."Mol. Cell. Biol. 26:8964-8975(2006) [PubMed] [Europe PMC] [Abstract]