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Melanoma Antigen Family A6 (MAGEA6)

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MAGE6; CT1.6; Cancer/Testis Antigen Family 1, Member 6; Melanoma-Associated Antigen 6

Melanoma Antigen Family A6 (MAGEA6)
CCC Q285
HGNC 6804
PubMed 22707303
UniProt P43360
MAGEA6 is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Two transcript variants encoding the same protein have been identified for this gene.
MAGE6 cDNA was cloned from a melanoma cell cDNA library. The gene encodes a 314-amino acid polypeptide that is 99% identical to MAGE3. RT-PCR revealed that MAGE6 is expressed in a variety of cancer cell lines, but among normal tissues only in testis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Melanoma Antigen Family A6 (MAGEA6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Melanoma Antigen Family A6 (MAGEA6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Melanoma Antigen Family A6 (MAGEA6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Melanoma Antigen Family A6 (MAGEA6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Melanoma Antigen Family A6 (MAGEA6) ELISA Kit Customized Service Offer
  1. "Structure, chromosomal localization, and expression of 12 genes of the MAGE family."Immunogenetics 40:360-369(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and analysis of MAGE-1-related genes."Biochem. Biophys. Res. Commun. 202:549-555(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Sequence analysis of the MAGE gene family encoding human tumor-rejection antigens."Gene 160:287-290(1995) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "MAGE-A, mMage-b, and MAGE-C proteins form complexes with KAP1 and suppress p53-dependent apoptosis in MAGE-positive cell lines."Cancer Res. 67:9954-9962(2007) [PubMed] [Europe PMC] [Abstract]
  7. "MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases."Mol. Cell 39:963-974(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Terminal osseous dysplasia is caused by a single recurrent mutation in the FLNA gene."Am. J. Hum. Genet. 87:146-153(2010) [PubMed] [Europe PMC] [Abstract]