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Potassium Inwardly Rectifying Channel Subfamily J, Member 5 (KCNJ5)

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Kir3.4; CIR; KATP1; GIRK4; G protein-activated inward rectifier potassium channel 4; Cardiac inward rectifier; Inward rectifier K(+) channel Kir3.4; Heart KATP channel

Potassium Inwardly Rectifying Channel Subfamily J, Member 5 (KCNJ5)
CCC Q277
HGNC 6266
MGI 104755
PubMed 24037882
RGD 61971
UniProt P48544
Wiki KCNJ5
KCNJ5 is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. It may associate with two other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex. Girk4 associated with Girk1 during or shortly after subunit synthesis and allowed appropriate glycosylation of the Girk1 subunit to a form seen in native atrial tissue. The C terminus of Girk4 was required for cell surface localization. Girk1 appeared intracellular in atrial myocytes isolated from Girk4-knockout mice, and it was not maturely glycosylated, supporting an essential role for GIRK4 in processing and cell surface localization of GIRK1/GIRK4 channels in vivo.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Potassium Inwardly Rectifying Channel Subfamily J, Member 5 (KCNJ5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Potassium Inwardly Rectifying Channel Subfamily J, Member 5 (KCNJ5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Potassium Inwardly Rectifying Channel Subfamily J, Member 5 (KCNJ5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Potassium Inwardly Rectifying Channel Subfamily J, Member 5 (KCNJ5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Potassium Inwardly Rectifying Channel Subfamily J, Member 5 (KCNJ5) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Potassium Inwardly Rectifying Channel Subfamily J, Member 5 (KCNJ5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Potassium Inwardly Rectifying Channel Subfamily J, Member 5 (KCNJ5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Potassium Inwardly Rectifying Channel Subfamily J, Member 5 (KCNJ5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Potassium Inwardly Rectifying Channel Subfamily J, Member 5 (KCNJ5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Potassium Inwardly Rectifying Channel Subfamily J, Member 5 (KCNJ5) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ277Ra01 Recombinant Potassium Inwardly Rectifying Channel Subfamily J, Member 5 (KCNJ5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ277Ra21 Monoclonal Antibody to Potassium Inwardly Rectifying Channel Subfamily J, Member 5 (KCNJ5) WB; IHC; ICC; IP.
PAQ277Ra01 Polyclonal Antibody to Potassium Inwardly Rectifying Channel Subfamily J, Member 5 (KCNJ5) WB; IHC; ICC; IP.
Assay Kits SEQ277Ra ELISA Kit for Potassium Inwardly Rectifying Channel Subfamily J, Member 5 (KCNJ5) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Cloning and functional expression of a rat heart KATP channel."Nature 370:456-459(1994) [PubMed] [Europe PMC] [Abstract]
  2. ErratumNature 378:792-792(1995) [PubMed] [Europe PMC] [Abstract]
  3. "A G-protein-activated inwardly rectifying K+ channel (GIRK4) from human hippocampus associates with other GIRK channels."J. Neurosci. 16:930-938(1996) [PubMed] [Europe PMC] [Abstract]
  4. "Co-expression of human Kir3 subunits can yield channels with different functional properties."Cell. Signal. 11:871-883(1999) [PubMed] [Europe PMC] [Abstract]
  5. "Functional characterization and localization of a cardiac-type inwardly rectifying K+ channel."Recept. Channels 3:299-315(1995) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "K+ channel mutations in adrenal aldosterone-producing adenomas and hereditary hypertension."Science 331:768-772(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Identification of a Kir3.4 mutation in congenital long QT syndrome." Am. J. Hum. Genet. 86:872-880(2010) [PubMed] [Europe PMC] [Abstract]
  11. "KCNJ5 mutations in European families with nonglucocorticoid remediable familial hyperaldosteronism." Hypertension 59:235-240(2012) [PubMed] [Europe PMC] [Abstract]
  12. "Prevalence, clinical, and molecular correlates of KCNJ5 mutations in primary aldosteronism." Hypertension 59:592-598(2012) [PubMed] [Europe PMC] [Abstract]
  13. "Comprehensive re-sequencing of adrenal aldosterone producing lesions reveal three somatic mutations near the KCNJ5 potassium channel selectivity filter." PLoS ONE 7:E41926-E41926(2012) [PubMed] [Europe PMC] [Abstract]
  14. "Hypertension with or without adrenal hyperplasia due to different inherited mutations in the potassium channel KCNJ5."Proc. Natl. Acad. Sci. U.S.A. 109:2533-2538(2012) [PubMed] [Europe PMC] [Abstract]