![Cellular Repressor Of E1A Stimulated Genes 1 (CREG1)](/upload/item/img/Cellular-Repressor-Of-E1A-Stimulated-Genes-1-(CREG1)-84264.jpg)
In transfection assays, CREG represses transcription and antagonizes 12SE1A-mediated activation of both the adenovirus E2 and cellular hsp70 promoters. CREG also antagonizes E1A-mediated transformation, as expression of CREG reduces the efficiency with which E1A and the oncogene ras cooperate to transform primary cells. Binding sites for E2F, a key transcriptional regulator of cell cycle progression, were found to be required for repression of the adenovirus E2 promoter by CREG, and CREG was shown to inhibit activation by E2F. Since both the adenovirus E1A protein and transcriptional activation by E2F function to promote cellular proliferation, the results presented here suggest that CREG activity may contribute to the transcriptional control of cell growth and differentiation.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPQ264Hu01 | Recombinant Cellular Repressor Of E1A Stimulated Genes 1 (CREG1) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAQ264Hu01 | Polyclonal Antibody to Cellular Repressor Of E1A Stimulated Genes 1 (CREG1) | WB; IHC |
MAQ264Hu21 | Monoclonal Antibody to Cellular Repressor Of E1A Stimulated Genes 1 (CREG1) | WB; IHC; ICC; IP. | |
Assay Kits | SEQ264Hu | ELISA Kit for Cellular Repressor Of E1A Stimulated Genes 1 (CREG1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPQ264Mu01 | Recombinant Cellular Repressor Of E1A Stimulated Genes 1 (CREG1) | Positive Control; Immunogen; SDS-PAGE; WB. |
RPQ264Mu02 | Recombinant Cellular Repressor Of E1A Stimulated Genes 1 (CREG1) | Positive Control; Immunogen; SDS-PAGE; WB. | |
Antibodies | PAQ264Mu01 | Polyclonal Antibody to Cellular Repressor Of E1A Stimulated Genes 1 (CREG1) | WB; IHC; ICC; IP. |
PAQ264Mu02 | Polyclonal Antibody to Cellular Repressor Of E1A Stimulated Genes 1 (CREG1) | WB; IHC; ICC; IP. | |
Assay Kits | SEQ264Mu | ELISA Kit for Cellular Repressor Of E1A Stimulated Genes 1 (CREG1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Cellular Repressor Of E1A Stimulated Genes 1 (CREG1) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Cellular Repressor Of E1A Stimulated Genes 1 (CREG1) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Cellular Repressor Of E1A Stimulated Genes 1 (CREG1) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Cellular Repressor Of E1A Stimulated Genes 1 (CREG1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Cellular Repressor Of E1A Stimulated Genes 1 (CREG1) | ELISA Kit Customized Service Offer |
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