Claudin 6 (CLDN6)
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet.
CLDN6 encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ257Hu01 Recombinant Claudin 6 (CLDN6) Positive Control; Immunogen; SDS-PAGE; WB.
RPQ257Hu02 Recombinant Claudin 6 (CLDN6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ257Hu21 Monoclonal Antibody to Claudin 6 (CLDN6) WB; IHC; ICC; IP.
PAQ257Hu01 Polyclonal Antibody to Claudin 6 (CLDN6) WB; IHC; ICC; IP.
Assay Kits SEQ257Hu ELISA Kit for Claudin 6 (CLDN6) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Claudin 6 (CLDN6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Claudin 6 (CLDN6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Claudin 6 (CLDN6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Claudin 6 (CLDN6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Claudin 6 (CLDN6) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Claudin 6 (CLDN6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Claudin 6 (CLDN6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Claudin 6 (CLDN6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Claudin 6 (CLDN6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Claudin 6 (CLDN6) ELISA Kit Customized Service Offer
  1. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Claudin-6 and claudin-9 function as additional coreceptors for hepatitis C virus."J. Virol. 81:12465-12471(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  6. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]