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CDC42 Binding Protein Kinase Beta (CDC42BPb)

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MRCKB; Serine/threonine-protein kinase MRCK beta; Myotonic dystrophy kinase-related CDC42-binding kinase beta

CDC42 Binding Protein Kinase Beta (CDC42BPb)
CCC Q246
HGNC 1738
MGI 2136459
PubMed 21471979
RGD 621753
UniProt Q9Y5S2
CDC42BPb encodes a member of the serine/threonine protein kinase family. The encoded protein contains a Cdc42/Rac-binding p21 binding domain resembling that of PAK kinase. The kinase domain of this protein is most closely related to that of myotonic dystrophy kinase-related ROK. Studies of the similar gene in rat suggested that this kinase may act as a downstream effector of Cdc42 in cytoskeletal reorganization. The p21 GTPases, Rho and Cdc42, regulate numerous cellular functions by binding to members of a serine/threonine protein kinase subfamily. Two of these p21 GTPase-regulated kinases, the myotonic dystrophy protein kinase-related Cdc42-binding kinases (MRCKalpha and beta), have been recently characterized in rat.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CDC42 Binding Protein Kinase Beta (CDC42BPb) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CDC42 Binding Protein Kinase Beta (CDC42BPb) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CDC42 Binding Protein Kinase Beta (CDC42BPb) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CDC42 Binding Protein Kinase Beta (CDC42BPb) CLIA Kit Customized Service Offer
n/a ELISA Kit for CDC42 Binding Protein Kinase Beta (CDC42BPb) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CDC42 Binding Protein Kinase Beta (CDC42BPb) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CDC42 Binding Protein Kinase Beta (CDC42BPb) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CDC42 Binding Protein Kinase Beta (CDC42BPb) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CDC42 Binding Protein Kinase Beta (CDC42BPb) CLIA Kit Customized Service Offer
n/a ELISA Kit for CDC42 Binding Protein Kinase Beta (CDC42BPb) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CDC42 Binding Protein Kinase Beta (CDC42BPb) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CDC42 Binding Protein Kinase Beta (CDC42BPb) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CDC42 Binding Protein Kinase Beta (CDC42BPb) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CDC42 Binding Protein Kinase Beta (CDC42BPb) CLIA Kit Customized Service Offer
n/a ELISA Kit for CDC42 Binding Protein Kinase Beta (CDC42BPb) ELISA Kit Customized Service Offer
  1. "Cloning and chromosomal localization of human Cdc42-binding protein kinase beta."Genomics 57:297-300(1999) [PubMed] [Europe PMC] [Abstract].
  2. "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract].
  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract].
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  6. "A tripartite complex containing MRCK modulates lamellar actomyosin retrograde flow."Cell 135:123-136(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Cdc42-dependent formation of the ZO-1/MRCKbeta complex at the leading edge controls cell migration."EMBO J. 30:665-678(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Chelerythrine perturbs lamellar actomyosin filaments by selective inhibition of myotonic dystrophy kinase-related Cdc42-binding kinase."FEBS Lett. 585:1260-1268(2011) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  16. "Co-crystal structures of inhibitors with MRCKbeta, a key regulator of tumor cell invasion."PLoS ONE 6:E24825-E24825(2011) [PubMed] [Europe PMC] [Abstract]
  17. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]