≡

Cyclin M4 (CNNM4)

[Edit]

ACDP4; Metal transporter CNNM4; Ancient conserved domain-containing protein 4

Cyclin M4 (CNNM4)
CCC Q210
HGNC 105
MGI 2151060
PubMed 19200525
RGD 1305571
UniProt Q6P4Q7
Acdp4 contains 4 transmembrane domains, 2 CBS domains, a DUF21 domain, and a cNMP-binding domain. It also has a leucine zipper and an amidation site. Northern blot analysis of mouse tissues detected highest Acdp4 expression in kidney, small intestine, and testis, with lower expression in all other tissues examined.
The ACDP4 gene, designated CNNM4 by the HUGO Nomenclature Committee, encodes a deduced 775-amino acid protein. Northern blot analysis revealed ubiquitous expression of CNNM4. Immunofluorescence studies showed that all 4 CNMM proteins are predominantly localized in the nucleus. CNNM4 contains 4 N-terminal transmembrane domains as well as a DUF21 domain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cyclin M4 (CNNM4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cyclin M4 (CNNM4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cyclin M4 (CNNM4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cyclin M4 (CNNM4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclin M4 (CNNM4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cyclin M4 (CNNM4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cyclin M4 (CNNM4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cyclin M4 (CNNM4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cyclin M4 (CNNM4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclin M4 (CNNM4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cyclin M4 (CNNM4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cyclin M4 (CNNM4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cyclin M4 (CNNM4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cyclin M4 (CNNM4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclin M4 (CNNM4) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Mutations in CNNM4 cause recessive cone-rod dystrophy with amelogenesis imperfecta."Am. J. Hum. Genet. 84:259-265(2009) [PubMed] [Europe PMC] [Abstract]
  5. "Molecular cloning and characterization of a novel gene family of four ancient conserved domain proteins (ACDP)."Gene 306:37-44(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Physical interaction and functional coupling between ACDP4 and the intracellular ion chaperone COX11, an implication of the role of ACDP4 in essential metal ion transport and homeostasis."Mol. Pain 1:15-15(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Membrane topology and intracellular processing of Cyclin M2 (CNNM2)."J. Biol. Chem. 287:13644-13655(2012) [PubMed] [Europe PMC] [Abstract]
  9. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Mutations in CNNM4 cause Jalili syndrome, consisting of autosomal-recessive cone-rod dystrophy and amelogenesis imperfecta."Am. J. Hum. Genet. 84:266-273(2009) [PubMed] [Europe PMC] [Abstract]