Calcium Channel Flower Domain Containing Protein 1 (CACFD1)

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Flower; C9orf7; Calcium channel flower homolog

Calcium Channel Flower Domain Containing Protein 1 (CACFD1)
Drosophila Flower protein associated with synaptic vesicles and localized at periactive zones upon synaptic vesicle fusion. Loss of Flower resulted in impaired intracellular resting Ca(2+) levels and impaired endocytosis. Flower formed multimers and formed a channel to control Ca(2+) influx in insect salivary gland cells. It also supported Ca(2+) influx in reconstituted proteoliposomes. Downregulation of Flower in Drosophila impaired Ca(2+) handling at presynaptic terminals.
Yao et al. (2009) cloned Drosophila Flower, and by database analysis they identified orthologs in several species, including mouse and human. The deduced 172-amino acid human protein contains 4 transmembrane domains conserved in Flower orthologs.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calcium Channel Flower Domain Containing Protein 1 (CACFD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calcium Channel Flower Domain Containing Protein 1 (CACFD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcium Channel Flower Domain Containing Protein 1 (CACFD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calcium Channel Flower Domain Containing Protein 1 (CACFD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium Channel Flower Domain Containing Protein 1 (CACFD1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calcium Channel Flower Domain Containing Protein 1 (CACFD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calcium Channel Flower Domain Containing Protein 1 (CACFD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcium Channel Flower Domain Containing Protein 1 (CACFD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calcium Channel Flower Domain Containing Protein 1 (CACFD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium Channel Flower Domain Containing Protein 1 (CACFD1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calcium Channel Flower Domain Containing Protein 1 (CACFD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calcium Channel Flower Domain Containing Protein 1 (CACFD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcium Channel Flower Domain Containing Protein 1 (CACFD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calcium Channel Flower Domain Containing Protein 1 (CACFD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium Channel Flower Domain Containing Protein 1 (CACFD1) ELISA Kit Customized Service Offer
  1. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]