≡

Cell Division Cycle Protein 25B (CDC25B)

[Edit]

CDC25HU2; M-phase inducer phosphatase 2; Dual specificity phosphatase Cdc25B

Cell Division Cycle Protein 25B (CDC25B)
CCC Q124
HGNC 1726
MGI 99701
PubMed 23160377
RGD 621500
UniProt P30305
Wiki CDC25B
CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2.
CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist. In vitro, p38 binds and phosphorylates CDC25B at serines 309 and 361, and CDC25C at serine-216; phosphorylation of these residues is required for binding to 14-3-3 proteins.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ124Hu01 Recombinant Cell Division Cycle Protein 25B (CDC25B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAQ124Hu01 Polyclonal Antibody to Cell Division Cycle Protein 25B (CDC25B) WB; IHC; ICC; IP.
LAQ124Hu71 Biotin-Linked Polyclonal Antibody to Cell Division Cycle Protein 25B (CDC25B) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Cell Division Cycle Protein 25B (CDC25B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cell Division Cycle Protein 25B (CDC25B) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cell Division Cycle Protein 25B (CDC25B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cell Division Cycle Protein 25B (CDC25B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cell Division Cycle Protein 25B (CDC25B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cell Division Cycle Protein 25B (CDC25B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cell Division Cycle Protein 25B (CDC25B) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cell Division Cycle Protein 25B (CDC25B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cell Division Cycle Protein 25B (CDC25B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cell Division Cycle Protein 25B (CDC25B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cell Division Cycle Protein 25B (CDC25B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cell Division Cycle Protein 25B (CDC25B) ELISA Kit Customized Service Offer
  1. "Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins."Cell 67:1181-1194(1991) [PubMed] [Europe PMC] [Abstract]
  2. "An additional homolog of the fission yeast cdc25+ gene occurs in humans and is highly expressed in some cancer cells."New Biol. 3:959-968(1991) [PubMed] [Europe PMC] [Abstract]
  3. "Alternative splicing of the human CDC25B tyrosine phosphatase. Possible implications for growth control?"Oncogene 14:2485-2495(1997) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase."Nature 411:102-107(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation."Oncogene 21:7630-7641(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function."J. Biol. Chem. 279:31164-31170(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2-M transition."J. Cell Sci. 117:2523-2531(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase."Nat. Cell Biol. 6:884-891(2004) [PubMed] [Europe PMC] [Abstract]
  11. "CDC25B phosphorylated by pEg3 localizes to the centrosome and the spindle poles at mitosis."Cell Cycle 4:806-811(2005) [PubMed] [Europe PMC] [Abstract]
  12. "MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation."Mol. Cell 17:37-48(2005) [PubMed] [Europe PMC] [Abstract]
  13. "Rho GTPases regulate PRK2/PKN2 to control entry into mitosis and exit from cytokinesis."EMBO J. 26:1624-1636(2007) [PubMed] [Europe PMC] [Abstract]
  14. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  17. "Crystal structure of the catalytic subunit of Cdc25B required for G2/M phase transition of the cell cycle."J. Mol. Biol. 293:559-568(1999) [PubMed] [Europe PMC] [Abstract]