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Cell Division Cycle Protein 25C (CDC25C)

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CDC25; M-phase inducer phosphatase 3; Dual specificity phosphatase Cdc25C

Cell Division Cycle Protein 25C (CDC25C)
CCC Q123
HGNC 1727
MGI 88350
PubMed 23637932
RGD 1311875
UniProt P30307
Wiki CDC25C
CDC25C is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis.The product of the human cdc25 homolog shared a conserved C-terminal domain with the yeast and Drosophila cdc25 proteins. Furthermore, the human cdc25 homolog rescued a fission yeast temperature-sensitive mutant form of cdc25, indicating functional as well as structural conservation of cdc25 homologs. The human gene encodes a protein with a predicted molecular mass of 53,000 daltons whose C-terminal domain shares about 37% sequence identity with the fission yeast cdc25 mitotic inducer.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cell Division Cycle Protein 25C (CDC25C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cell Division Cycle Protein 25C (CDC25C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cell Division Cycle Protein 25C (CDC25C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cell Division Cycle Protein 25C (CDC25C) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cell Division Cycle Protein 25C (CDC25C) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cell Division Cycle Protein 25C (CDC25C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cell Division Cycle Protein 25C (CDC25C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cell Division Cycle Protein 25C (CDC25C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cell Division Cycle Protein 25C (CDC25C) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cell Division Cycle Protein 25C (CDC25C) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cell Division Cycle Protein 25C (CDC25C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cell Division Cycle Protein 25C (CDC25C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cell Division Cycle Protein 25C (CDC25C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cell Division Cycle Protein 25C (CDC25C) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cell Division Cycle Protein 25C (CDC25C) ELISA Kit Customized Service Offer
  1. "Human homolog of fission yeast cdc25 mitotic inducer is predominantly expressed in G2."Proc. Natl. Acad. Sci. U.S.A. 87:5139-5143(1990) [PubMed] [Europe PMC] [Abstract]
  2. "An additional transcript of the cdc25C gene from A431 cells encodes a functional protein."Int. J. Oncol. 17:1251-1258(2000) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Alternative splicing in the regulatory region of the human phosphatases CDC25A and CDC25C."Eur. J. Cell Biol. 79:810-815(2000) [PubMed] [Europe PMC] [Abstract]
  5. "Differential expression of cdc25 cell-cycle-activating phosphatases in human colorectal carcinoma."Lab. Invest. 81:465-473(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Activation of p34cdc2 protein kinase by microinjection of human cdc25C into mammalian cells. Requirement for prior phosphorylation of cdc25C by p34cdc2 on sites phosphorylated at mitosis."J. Biol. Chem. 269:5989-6000(1994) [PubMed] [Europe PMC] [Abstract]
  7. "The physical association and phosphorylation of Cdc25C protein phosphatase by Prk."Oncogene 18:6029-6036(1999) [PubMed] [Europe PMC] [Abstract]
  8. "The human polo-like kinase, PLK, regulates cdc2/cyclin B through phosphorylation and activation of the cdc25C phosphatase."Cell. Signal. 12:405-411(2000) [PubMed] [Europe PMC] [Abstract]
  9. "Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase."Nature 411:102-107(2001) [PubMed] [Europe PMC] [Abstract]
  10. "Proteomic screen finds pSer/pThr-binding domain localizing Plk1 to mitotic substrates."Science 299:1228-1231(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function."J. Biol. Chem. 279:31164-31170(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Cdc25C phosphorylation on serine 191 by Plk3 promotes its nuclear translocation."Oncogene 23:2658-2663(2004) [PubMed] [Europe PMC] [Abstract]
  13. "The human immunodeficiency virus Vpr protein binds Cdc25C: implications for G2 arrest."Virology 318:337-349(2004) [PubMed] [Europe PMC] [Abstract]
  14. "MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation."Mol. Cell 17:37-48(2005) [PubMed] [Europe PMC] [Abstract]
  15. "Human Plk4 phosphorylates Cdc25C."Cell Cycle 7:545-547(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  17. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  18. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  19. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]