Cell Adhesion Molecule With Homology To L1CAM (CHL1)

CHL1 is a member of the L1 gene family of neural cell adhesion molecules. It is a neural recognition molecule that may be involved in signal transduction pathways. The deletion of one copy of this gene may be responsible for mental defects in patients with 3p- syndrome. Several alternatively spliced transcript variants of this gene have been described, but their full length nature is not known.The predicted CALL protein contains 1,224 amino acids and has a calculated molecular mass of 136 kD. It has a signal peptide, followed by 6 immunoglobulin (Ig) domains, 4 fibronectintype III (FNIII) domains, a single-pass transmembrane peptide, and a 105-amino acid cytoplasmic domain. The cytoplasmic domain of CALL is conserved among other members of the L1 subfamily and features sequence motifs that may involve CALL in signal transduction pathways.