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Rabconnectin 3 (RC3)

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DMXL2; Dmx-Like 2

Rabconnectin 3 (RC3)
CCC Q085
HGNC 2938
MGI 2444630
PubMed 20810660
RGD 1586163
UniProt Q8TDJ6
DMXL2shares significant homology with DMXL1. RT-PCR ELISA detected moderate expression in brain, lung, liver, kidney, testis, and ovary. Expression was low in heart and undetectable in skeletal muscle, pancreas, and spleen.
The deduced 3,036-amino acid protein has a calculated molecular mass of 339.8 kD and contains 12 WD domains. Western blot analysis of rat tissues showed abundant expression of Dmxl2 in brain only, and subcellular distribution analysis revealed enrichment in the synaptic vesicle fraction. Immunofluorescence and immunoelectron microscopy of mouse hippocampus and primary cultured rat hippocampal neurons showed that Dmxl2 was concentrated on synaptic vesicles at synapses.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Rabconnectin 3 (RC3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Rabconnectin 3 (RC3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Rabconnectin 3 (RC3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Rabconnectin 3 (RC3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Rabconnectin 3 (RC3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Rabconnectin 3 (RC3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Rabconnectin 3 (RC3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Rabconnectin 3 (RC3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Rabconnectin 3 (RC3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Rabconnectin 3 (RC3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Rabconnectin 3 (RC3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Rabconnectin 3 (RC3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Rabconnectin 3 (RC3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Rabconnectin 3 (RC3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Rabconnectin 3 (RC3) ELISA Kit Customized Service Offer
  1. "Rabconnectin-3, a novel protein that binds both GDP/GTP exchange protein and GTPase-activating protein for Rab3 small G protein family."J. Biol. Chem. 277:9629-9632(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  4. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Haploinsufficiency of Dmxl2, encoding a synaptic protein, causes infertility associated with a loss of GnRH neurons in mouse."PLoS Biol. 12:E1001952-E1001952(2014) [PubMed] [Europe PMC] [Abstract]