Diptheria Toxin Resistance Protein Required For Diphthamide Biosynthesis Like Protein 2 (DPH2L2)
[Edit]DPH2; DPH2L2; Diphthamide biosynthesis protein 2 homolog-like 2; Diphthamide biosynthesis protein 2
DPH2L2 is one of two human genes similar to the yeast gene dph2. The yeast gene was identified by its ability to complement a diphthamide mutant strain, and thus probably functions in diphthamide biosynthesis. Diphthamide is a post-translationally modified histidine residue present in elongation factor 2 (EF2) that is the target of diphtheria toxin ADP-ribosylation. Two transcript variants encoding different isoforms have been found for this gene.
Mouse Dph2 could complement the DT-resistant phenotype of diphthamide-deficient mutant Chinese hamster ovary cell lines. Immunoprecipitation analysis revealed that yeast and mouse Dph1 and Dph2 interacted, suggesting that these enzymes may function in diphthamide biosynthesis as a dimer or multimer.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Diptheria Toxin Resistance Protein Required For Diphthamide Biosynthesis Like Protein 2 (DPH2L2) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Diptheria Toxin Resistance Protein Required For Diphthamide Biosynthesis Like Protein 2 (DPH2L2) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Diptheria Toxin Resistance Protein Required For Diphthamide Biosynthesis Like Protein 2 (DPH2L2) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Diptheria Toxin Resistance Protein Required For Diphthamide Biosynthesis Like Protein 2 (DPH2L2) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Diptheria Toxin Resistance Protein Required For Diphthamide Biosynthesis Like Protein 2 (DPH2L2) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Diptheria Toxin Resistance Protein Required For Diphthamide Biosynthesis Like Protein 2 (DPH2L2) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Diptheria Toxin Resistance Protein Required For Diphthamide Biosynthesis Like Protein 2 (DPH2L2) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Diptheria Toxin Resistance Protein Required For Diphthamide Biosynthesis Like Protein 2 (DPH2L2) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Diptheria Toxin Resistance Protein Required For Diphthamide Biosynthesis Like Protein 2 (DPH2L2) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Diptheria Toxin Resistance Protein Required For Diphthamide Biosynthesis Like Protein 2 (DPH2L2) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Diptheria Toxin Resistance Protein Required For Diphthamide Biosynthesis Like Protein 2 (DPH2L2) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Diptheria Toxin Resistance Protein Required For Diphthamide Biosynthesis Like Protein 2 (DPH2L2) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Diptheria Toxin Resistance Protein Required For Diphthamide Biosynthesis Like Protein 2 (DPH2L2) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Diptheria Toxin Resistance Protein Required For Diphthamide Biosynthesis Like Protein 2 (DPH2L2) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Diptheria Toxin Resistance Protein Required For Diphthamide Biosynthesis Like Protein 2 (DPH2L2) | ELISA Kit Customized Service Offer |
- "Cloning and localization of a human diphthamide biosynthesis-like protein-2 gene, DPH2L2."Genomics 52:186-191(1998) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
- "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
- "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
- "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
- "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
- "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]