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Fc Fragment Of IgG Low Affinity IIb, Receptor (FcgR2B)

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CD32; FCG2; FCGR2; IGFR2; Low affinity immunoglobulin gamma Fc region receptor II-b

Fc Fragment Of IgG Low Affinity IIb, Receptor (FcgR2B)
CCC Q061
HGNC 3618
MGI 95499
PubMed 14508797
RGD 631331
UniProt P31994
Wiki FCGR2B
FCGR2B is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene.Sequence analysis predicted that the 291-amino acid protein has a 42-residue signal sequence; 2 extracellular Ig-like domains with 3 potential N-glycosylation sites; a transmembrane region; and a 43-amino acid cytoplasmic region. Immunofluorescence microscopy demonstrated surface expression of FCGR2B, and prolonged incubation with ligand led to endocytosis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ061Hu01 Recombinant Fc Fragment Of IgG Low Affinity IIb, Receptor (FcgR2B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Fc Fragment Of IgG Low Affinity IIb, Receptor (FcgR2B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fc Fragment Of IgG Low Affinity IIb, Receptor (FcgR2B) Polyclonal Antibody Customized Service Offer
Assay Kits SEQ061Hu ELISA Kit for Fc Fragment Of IgG Low Affinity IIb, Receptor (FcgR2B) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Fc Fragment Of IgG Low Affinity IIb, Receptor (FcgR2B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Fc Fragment Of IgG Low Affinity IIb, Receptor (FcgR2B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fc Fragment Of IgG Low Affinity IIb, Receptor (FcgR2B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fc Fragment Of IgG Low Affinity IIb, Receptor (FcgR2B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fc Fragment Of IgG Low Affinity IIb, Receptor (FcgR2B) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Fc Fragment Of IgG Low Affinity IIb, Receptor (FcgR2B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Fc Fragment Of IgG Low Affinity IIb, Receptor (FcgR2B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fc Fragment Of IgG Low Affinity IIb, Receptor (FcgR2B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fc Fragment Of IgG Low Affinity IIb, Receptor (FcgR2B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fc Fragment Of IgG Low Affinity IIb, Receptor (FcgR2B) ELISA Kit Customized Service Offer
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  2. "Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes."J. Exp. Med. 170:1369-1385(1989) [PubMed] [Europe PMC] [Abstract]
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  7. "Association of immunoglobulin G Fc receptor II with Src-like protein-tyrosine kinase Fgr in neutrophils."Proc. Natl. Acad. Sci. U.S.A. 90:6305-6309(1993) [PubMed] [Europe PMC] [Abstract]
  8. "In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation."Mol. Cell. Biol. 16:4735-4743(1996) [PubMed] [Europe PMC] [Abstract]
  9. "Fc gamma receptor type IIb induced recruitment of inositol and protein phosphatases to the signal transductory complex of human B-cell."Immunol. Lett. 57:159-164(1997) [PubMed] [Europe PMC] [Abstract]
  10. "Measles virus nucleoprotein induces cell-proliferation arrest and apoptosis through NTAIL-NR and NCORE-FcgammaRIIB1 interactions, respectively."J. Gen. Virol. 86:1771-1784(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Crystal structure of the soluble form of the human fcgamma-receptor IIb: a new member of the immunoglobulin superfamily at 1.7 A resolution."EMBO J. 18:1095-1103(1999) [PubMed] [Europe PMC] [Abstract]
  12. "Interaction of a human Fc gamma RIIb1 (CD32) isoform with murine and human IgG subclasses."Int. Immunol. 5:239-247(1993) [PubMed] [Europe PMC] [Abstract]
  13. "Systemic lupus erythematosus-associated defects in the inhibitory receptor FcgammaRIIb reduce susceptibility to malaria."Proc. Natl. Acad. Sci. U.S.A. 104:7169-7174(2007) [PubMed] [Europe PMC] [Abstract]
  14. "A defunctioning polymorphism in FCGR2B is associated with protection against malaria but susceptibility to systemic lupus erythematosus."Proc. Natl. Acad. Sci. U.S.A. 107:7881-7885(2010) [PubMed] [Europe PMC] [Abstract]