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Fc Fragment Of IgG Low Affinity IIb, Receptor (FcgR2B)

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CD32; FCG2; FCGR2; IGFR2; Low affinity immunoglobulin gamma Fc region receptor II-b

Fc Fragment Of IgG Low Affinity IIb, Receptor (FcgR2B)
CCC Q061
HGNC 3618
MGI 95499
PubMed 14508797
RGD 631331
UniProt P31994
Wiki FCGR2B
FCGR2B is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene.Sequence analysis predicted that the 291-amino acid protein has a 42-residue signal sequence; 2 extracellular Ig-like domains with 3 potential N-glycosylation sites; a transmembrane region; and a 43-amino acid cytoplasmic region. Immunofluorescence microscopy demonstrated surface expression of FCGR2B, and prolonged incubation with ligand led to endocytosis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ061Hu01 Recombinant Fc Fragment Of IgG Low Affinity IIb, Receptor (FcgR2B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAQ061Hu01 Polyclonal Antibody to Fc Fragment Of IgG Low Affinity IIb, Receptor (FcgR2B) WB; IHC; ICC; IP.
Assay Kits SEQ061Hu ELISA Kit for Fc Fragment Of IgG Low Affinity IIb, Receptor (FcgR2B) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Fc Fragment Of IgG Low Affinity IIb, Receptor (FcgR2B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Fc Fragment Of IgG Low Affinity IIb, Receptor (FcgR2B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fc Fragment Of IgG Low Affinity IIb, Receptor (FcgR2B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fc Fragment Of IgG Low Affinity IIb, Receptor (FcgR2B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fc Fragment Of IgG Low Affinity IIb, Receptor (FcgR2B) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Fc Fragment Of IgG Low Affinity IIb, Receptor (FcgR2B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Fc Fragment Of IgG Low Affinity IIb, Receptor (FcgR2B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fc Fragment Of IgG Low Affinity IIb, Receptor (FcgR2B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fc Fragment Of IgG Low Affinity IIb, Receptor (FcgR2B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fc Fragment Of IgG Low Affinity IIb, Receptor (FcgR2B) ELISA Kit Customized Service Offer
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  7. "Association of immunoglobulin G Fc receptor II with Src-like protein-tyrosine kinase Fgr in neutrophils."Proc. Natl. Acad. Sci. U.S.A. 90:6305-6309(1993) [PubMed] [Europe PMC] [Abstract]
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  9. "Fc gamma receptor type IIb induced recruitment of inositol and protein phosphatases to the signal transductory complex of human B-cell."Immunol. Lett. 57:159-164(1997) [PubMed] [Europe PMC] [Abstract]
  10. "Measles virus nucleoprotein induces cell-proliferation arrest and apoptosis through NTAIL-NR and NCORE-FcgammaRIIB1 interactions, respectively."J. Gen. Virol. 86:1771-1784(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Crystal structure of the soluble form of the human fcgamma-receptor IIb: a new member of the immunoglobulin superfamily at 1.7 A resolution."EMBO J. 18:1095-1103(1999) [PubMed] [Europe PMC] [Abstract]
  12. "Interaction of a human Fc gamma RIIb1 (CD32) isoform with murine and human IgG subclasses."Int. Immunol. 5:239-247(1993) [PubMed] [Europe PMC] [Abstract]
  13. "Systemic lupus erythematosus-associated defects in the inhibitory receptor FcgammaRIIb reduce susceptibility to malaria."Proc. Natl. Acad. Sci. U.S.A. 104:7169-7174(2007) [PubMed] [Europe PMC] [Abstract]
  14. "A defunctioning polymorphism in FCGR2B is associated with protection against malaria but susceptibility to systemic lupus erythematosus."Proc. Natl. Acad. Sci. U.S.A. 107:7881-7885(2010) [PubMed] [Europe PMC] [Abstract]