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G Antigen 4 (GAGE4)

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CT4.4; Cancer/Testis Antigen Family 4 Member 4

G Antigen 4 (GAGE4)
CCC Q053
HGNC 4101
UniProt Q13068
Human melanoma cells express several distinct antigens that are recognized by autologous cytolytic T lymphocytes (CTLs). One class of these antigens is encoded by genes, such as MAGE1 (MAGEA1), MAGE3 (MAGEA3), and BAGE, that are expressed in a large fraction of tumors of various histologic types but are silent in normal adult tissues, except for testis. The GAGE2 to -6 cDNAs differ mainly by single nucleotide substitutions that are scattered throughout the sequence.
The deduced GAGE4 protein has 117 amino acids. RT-PCR using primers common to GAGE1 to -6 found expression of these genes in various tumors but no expression in any normal adult tissue tested except testis.GAGE4 is 1 of several copies of a GAGE gene repeated on chromosome Xp11.23.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant G Antigen 4 (GAGE4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to G Antigen 4 (GAGE4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to G Antigen 4 (GAGE4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for G Antigen 4 (GAGE4) CLIA Kit Customized Service Offer
n/a ELISA Kit for G Antigen 4 (GAGE4) ELISA Kit Customized Service Offer
  1. "A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma."J. Exp. Med. 182:689-698(1995) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Characterization of the GAGE genes that are expressed in various human cancers and in normal testis."Cancer Res. 59:3157-3165(1999) [PubMed] [Europe PMC] [Abstract]
  5. "An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members."Tissue Antigens 71:187-192(2008) [PubMed] [Europe PMC] [Abstract]