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P Antigen Family, Member 4 (PAGE4)

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GAGEC1; G Antigen Family C 1

P Antigen Family, Member 4 (PAGE4)
CCC Q047
HGNC 4108
UniProt O60829
PAGE4 is a member of the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in prostate and prostate cancer, but is also expressed in other male and female reproductive tissues including testis, fallopian tube, uterus, and placenta, as well as in testicular cancer and uterine cancer. The protein encoded by this gene shares sequence similarity with other GAGE/PAGE proteins, and also belongs to a family of CT (cancer-testis) antigens.
Sensitivity and specificity of the assay were 90% and 77%, respectively, and positive and negative predictive values were 74% and 91%, respectively. Prostate volume and presence of prostate cancer did not appear to alter the marker levels.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant P Antigen Family, Member 4 (PAGE4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to P Antigen Family, Member 4 (PAGE4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to P Antigen Family, Member 4 (PAGE4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for P Antigen Family, Member 4 (PAGE4) CLIA Kit Customized Service Offer
n/a ELISA Kit for P Antigen Family, Member 4 (PAGE4) ELISA Kit Customized Service Offer
  1. "PAGE-1, an X chromosome-linked GAGE-like gene that is expressed in normal and neoplastic prostate, testis, and uterus."Proc. Natl. Acad. Sci. U.S.A. 95:10757-10762(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]