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Histone Cluster 1, H2bl (HIST1H2BL)

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H2BFC; H2B/c; H2B Histone Family Member C

Histone Cluster 1, H2bl (HIST1H2BL)
CCC Q015
HGNC 4748
MGI 2448403
PubMed 9439656
UniProt Q99880
Wiki HIST1H2BL
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes.
HIST1H2BL is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. Albig and Doenecke (1997) characterized a second cluster of 16 histone genes, including H2B/c, located 2 Mb centromeric to the major histone gene cluster.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Histone Cluster 1, H2bl (HIST1H2BL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Histone Cluster 1, H2bl (HIST1H2BL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Histone Cluster 1, H2bl (HIST1H2BL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Histone Cluster 1, H2bl (HIST1H2BL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Histone Cluster 1, H2bl (HIST1H2BL) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Histone Cluster 1, H2bl (HIST1H2BL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Histone Cluster 1, H2bl (HIST1H2BL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Histone Cluster 1, H2bl (HIST1H2BL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Histone Cluster 1, H2bl (HIST1H2BL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Histone Cluster 1, H2bl (HIST1H2BL) ELISA Kit Customized Service Offer
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  2. "The human and mouse replication-dependent histone genes."Genomics 80:487-498(2002) [PubMed] [Europe PMC] [Abstract]
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  4. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Quantitative proteomic analysis of post-translational modifications of human histones."Mol. Cell. Proteomics 5:1314-1325(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase."Cell 113:507-517(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation."Mol. Cell 20:601-611(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Inhibition of core histones acetylation by carcinogenic nickel(II)."Mol. Cell. Biochem. 279:133-139(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II."Cell 125:703-717(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Characterization of histones H2A and H2B variants and their post-translational modifications by mass spectrometry."Mol. Cell. Proteomics 5:541-552(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification."Cell 146:1016-1028(2011) [PubMed] [Europe PMC] [Abstract]
  14. "The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylation."Mol. Cell 43:132-144(2011) [PubMed] [Europe PMC] [Abstract]
  15. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  16. "USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing."Genes Dev. 27:1581-1595(2013) [PubMed] [Europe PMC] [Abstract]