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Histone Cluster 1, H2bb (HIST1H2BB)

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H2BFF; H2B/f; H2B Histone Family Member F

Histone Cluster 1, H2bb (HIST1H2BB)
CCC Q012
HGNC 4751
MGI 2448377
PubMed 8227173
RGD 1598160
UniProt P33778
Wiki HIST1H2BB
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures.
HIST1H2BB is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Histone Cluster 1, H2bb (HIST1H2BB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Histone Cluster 1, H2bb (HIST1H2BB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Histone Cluster 1, H2bb (HIST1H2BB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Histone Cluster 1, H2bb (HIST1H2BB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Histone Cluster 1, H2bb (HIST1H2BB) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Histone Cluster 1, H2bb (HIST1H2BB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Histone Cluster 1, H2bb (HIST1H2BB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Histone Cluster 1, H2bb (HIST1H2BB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Histone Cluster 1, H2bb (HIST1H2BB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Histone Cluster 1, H2bb (HIST1H2BB) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Histone Cluster 1, H2bb (HIST1H2BB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Histone Cluster 1, H2bb (HIST1H2BB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Histone Cluster 1, H2bb (HIST1H2BB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Histone Cluster 1, H2bb (HIST1H2BB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Histone Cluster 1, H2bb (HIST1H2BB) ELISA Kit Customized Service Offer
  1. "Isolation and characterization of two human H1 histone genes within clusters of core histone genes."Genomics 10:940-948(1991) [PubMed] [Europe PMC] [Abstract]
  2. "The human and mouse replication-dependent histone genes."Genomics 80:487-498(2002) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Global regulation of post-translational modifications on core histones."J. Biol. Chem. 277:2579-2588(2002) [PubMed] [Europe PMC] [Abstract]
  5. "Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase."Cell 113:507-517(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation."Mol. Cell 20:601-611(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Inhibition of core histones acetylation by carcinogenic nickel(II)."Mol. Cell. Biochem. 279:133-139(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II."Cell 125:703-717(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification."Cell 146:1016-1028(2011) [PubMed] [Europe PMC] [Abstract]
  11. "The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylation."Mol. Cell 43:132-144(2011) [PubMed] [Europe PMC] [Abstract]
  12. "USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing."Genes Dev. 27:1581-1595(2013) [PubMed] [Europe PMC] [Abstract]