Histone Cluster 1, H2bo (HIST1H2BO)

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H2BFN; H2B/n; H2B.2; H2B Histone Family Member N

Histone Cluster 1, H2bo (HIST1H2BO)
Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures.
HIST1H2BO is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. By analysis of a YAC contig from chromosome 6p22-p21.3, Albig and Doenecke (1997) characterized a second cluster of 16 histone genes, including H2B.2, which they designated H2B/n, located 2 Mb centromeric to the major histone gene cluster.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Histone Cluster 1, H2bo (HIST1H2BO) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Histone Cluster 1, H2bo (HIST1H2BO) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Histone Cluster 1, H2bo (HIST1H2BO) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Histone Cluster 1, H2bo (HIST1H2BO) CLIA Kit Customized Service Offer
n/a ELISA Kit for Histone Cluster 1, H2bo (HIST1H2BO) ELISA Kit Customized Service Offer
  1. "A novel divergently transcribed human histone H2A/H2B gene pair."DNA Seq. 1:409-413(1991) [PubMed] [Europe PMC] [Abstract]
  2. "The human and mouse replication-dependent histone genes."Genomics 80:487-498(2002) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]