Histone Cluster 1, H3j (HIST1H3J)

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H3FJ; H3/j; H3 Histone Family Member J

Histone Cluster 1, H3j (HIST1H3J)
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures.HIST1H3J is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.Albig and Doenecke (1997) characterized a second cluster of 16 histone genes, including H3/j, located 2 Mb centromeric to the major histone gene cluster.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Histone Cluster 1, H3j (HIST1H3J) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Histone Cluster 1, H3j (HIST1H3J) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Histone Cluster 1, H3j (HIST1H3J) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Histone Cluster 1, H3j (HIST1H3J) CLIA Kit Customized Service Offer
n/a ELISA Kit for Histone Cluster 1, H3j (HIST1H3J) ELISA Kit Customized Service Offer
  1. "The primary structure and expression of four cloned human histone genes."Nucleic Acids Res. 11:7409-7425(1983) [PubMed] [Europe PMC] [Abstract]
  2. "Enhancer-facilitated expression of prokaryotic and eukaryotic genes using human histone gene 5' regulatory sequences."Biochem. Cell Biol. 64:277-289(1986) [PubMed] [Europe PMC] [Abstract]
  3. "Isolation and characterization of two human H1 histone genes within clusters of core histone genes."Genomics 10:940-948(1991) [PubMed] [Europe PMC] [Abstract]
  4. "Association of a human H1 histone gene with an H2A pseudogene and genes encoding H2B.1 and H3.1 histones."J. Cell. Biochem. 52:375-383(1993) [PubMed] [Europe PMC] [Abstract]
  5. "Characterization of the H1.5 gene completes the set of human H1 subtype genes."Gene 184:141-148(1997) [PubMed] [Europe PMC] [Abstract]
  6. "Human histone gene organization: nonregular arrangement within a large cluster."Genomics 40:314-322(1997) [PubMed] [Europe PMC] [Abstract]
  7. "The human histone gene cluster at the D6S105 locus."Hum. Genet. 101:284-294(1997) [PubMed] [Europe PMC] [Abstract]
  8. "The human and mouse replication-dependent histone genes."Genomics 80:487-498(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  10. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Human spleen histone H3. Isolation and amino acid sequence."J. Biochem. 90:1205-1211(1981) [PubMed] [Europe PMC] [Abstract]
  13. "Modifications of human histone H3 variants during mitosis."Biochemistry 44:13202-13213(2005) [PubMed] [Europe PMC] [Abstract]
  14. "Identification of a novel phosphorylation site on histone H3 coupled with mitotic chromosome condensation."J. Biol. Chem. 274:25543-25549(1999) [PubMed] [Europe PMC] [Abstract]
  15. "Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins."Nature 410:116-120(2001) [PubMed] [Europe PMC] [Abstract]
  16. "Aurora-B phosphorylates Histone H3 at serine28 with regard to the mitotic chromosome condensation."Genes Cells 7:11-17(2002) [PubMed] [Europe PMC] [Abstract]
  17. "Novel mitosis-specific phosphorylation of histone H3 at Thr11 mediated by Dlk/ZIP kinase."Nucleic Acids Res. 31:878-885(2003) [PubMed] [Europe PMC] [Abstract]
  18. "Ligand-dependent activation of the farnesoid X-receptor directs arginine methylation of histone H3 by CARM1."J. Biol. Chem. 279:54348-54357(2004) [PubMed] [Europe PMC] [Abstract]
  19. "Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks."Nature 432:406-411(2004) [PubMed] [Europe PMC] [Abstract]
  20. "Human PAD4 regulates histone arginine methylation levels via demethylimination."Science 306:279-283(2004) [PubMed] [Europe PMC] [Abstract]
  21. "The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment."Genes Dev. 19:472-488(2005) [PubMed] [Europe PMC] [Abstract]
  22. "Phosphorylation of Ser28 in histone H3 mediated by mixed lineage kinase-like mitogen-activated protein triple kinase alpha."J. Biol. Chem. 280:13545-13553(2005) [PubMed] [Europe PMC] [Abstract]
  23. "Protein identification using sequential ion/ion reactions and tandem mass spectrometry."Proc. Natl. Acad. Sci. U.S.A. 102:9463-9468(2005) [PubMed] [Europe PMC] [Abstract]
  24. "Expression patterns and post-translational modifications associated with mammalian histone H3 variants."J. Biol. Chem. 281:559-568(2006) [PubMed] [Europe PMC] [Abstract]
  25. "Mass spectrometric characterization of human histone H3: a bird's eye view."J. Proteome Res. 5:240-247(2006) [PubMed] [Europe PMC] [Abstract]
  26. "Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage."Mol. Cell 22:383-394(2006) [PubMed] [Europe PMC] [Abstract]
  27. "Quantitative proteomic analysis of post-translational modifications of human histones."Mol. Cell. Proteomics 5:1314-1325(2006) [PubMed] [Europe PMC] [Abstract]
  28. "Coactivator-associated arginine methyltransferase-1 enhances nuclear factor-kappaB-mediated gene transcription through methylation of histone H3 at arginine 17."Mol. Endocrinol. 20:1562-1573(2006) [PubMed] [Europe PMC] [Abstract]
  29. "Structural basis for histone N-terminal recognition by human peptidylarginine deiminase 4."Proc. Natl. Acad. Sci. U.S.A. 103:5291-5296(2006) [PubMed] [Europe PMC] [Abstract]
  30. "PRMT6-mediated methylation of R2 in histone H3 antagonizes H3 K4 trimethylation."Genes Dev. 21:3369-3380(2007) [PubMed] [Europe PMC] [Abstract]
  31. "Organismal differences in post-translational modifications in histones H3 and H4."J. Biol. Chem. 282:7641-7655(2007) [PubMed] [Europe PMC] [Abstract]
  32. "Identification of histone H3 lysine 36 acetylation as a highly conserved histone modification."J. Biol. Chem. 282:7632-7640(2007) [PubMed] [Europe PMC] [Abstract]
  33. "Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive."Nature 449:933-937(2007) [PubMed] [Europe PMC] [Abstract]
  34. "Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression."Cell 132:221-232(2008) [PubMed] [Europe PMC] [Abstract]
  35. "Arginine methylation of the histone H3 tail impedes effector binding."J. Biol. Chem. 283:3006-3010(2008) [PubMed] [Europe PMC] [Abstract]
  36. "Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation."Nat. Cell Biol. 10:53-60(2008) [PubMed] [Europe PMC] [Abstract]
  37. "Acetylation of histone H3 at the nucleosome dyad alters DNA-histone binding."J. Biol. Chem. 284:23312-23321(2009) [PubMed] [Europe PMC] [Abstract]
  38. "JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin."Nature 461:819-822(2009) [PubMed] [Europe PMC] [Abstract]
  39. "Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers."Cell 142:967-980(2010) [PubMed] [Europe PMC] [Abstract]
  40. "Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4."Nature 464:792-796(2010) [PubMed] [Europe PMC] [Abstract]
  41. "Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification."Cell 146:1016-1028(2011) [PubMed] [Europe PMC] [Abstract]
  42. "Histone H3 lysine 56 methylation regulates DNA replication through its interaction with PCNA."Mol. Cell 46:7-17(2012) [PubMed] [Europe PMC] [Abstract]
  43. "Lysyl oxidase-like 2 deaminates lysine 4 in histone H3."Mol. Cell 46:369-376(2012) [PubMed] [Europe PMC] [Abstract]
  44. "Regulation of transcription through acetylation of H3K122 on the lateral surface of the histone octamer."Cell 152:859-872(2013) [PubMed] [Europe PMC] [Abstract]
  45. "Molecular basis for the recognition of phosphorylated and phosphoacetylated histone h3 by 14-3-3."Mol. Cell 20:199-211(2005) [PubMed] [Europe PMC] [Abstract]
  46. "Double chromodomains cooperate to recognize the methylated histone H3 tail."Nature 438:1181-1185(2005) [PubMed] [Europe PMC] [Abstract]
  47. "Alteration of the nucleosomal DNA path in the crystal structure of a human nucleosome core particle."Nucleic Acids Res. 33:3424-3434(2005) [PubMed] [Europe PMC] [Abstract]