Hematopoietic Protein 1 (HEM1)
[Edit]NCKAP1L; NCK-Associated Protein 1 Like; Membrane-associated protein HEM-1
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HEM1 encodes a member of the HEM family of tissue-specific transmembrane proteins which are highly conserved from invertebrates through mammals. This gene is only expressed in hematopoietic cells. The encoded protein is a part of the Scar/WAVE complex which plays an important role in regulating cell shape in both metazoans and plants. Alternatively spliced transcript variants encoding different isoforms have been found.
Mice lacking Hem1 had defective F-actin polymerization and actin capping in lymphocytes and neutrophils due to loss of the Rac-controlled actin regulatory WAVE (WASF1) protein complex.Hem1-deficient neutrophils failed to migrate in response to chemotactic signals and were deficient in phagocytosing bacteria.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Hematopoietic Protein 1 (HEM1) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Hematopoietic Protein 1 (HEM1) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Hematopoietic Protein 1 (HEM1) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Hematopoietic Protein 1 (HEM1) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Hematopoietic Protein 1 (HEM1) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Hematopoietic Protein 1 (HEM1) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Hematopoietic Protein 1 (HEM1) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Hematopoietic Protein 1 (HEM1) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Hematopoietic Protein 1 (HEM1) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Hematopoietic Protein 1 (HEM1) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Hematopoietic Protein 1 (HEM1) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Hematopoietic Protein 1 (HEM1) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Hematopoietic Protein 1 (HEM1) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Hematopoietic Protein 1 (HEM1) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Hematopoietic Protein 1 (HEM1) | ELISA Kit Customized Service Offer |
- "The HEM proteins: a novel family of tissue-specific transmembrane proteins expressed from invertebrates through mammals with an essential function in oogenesis."J. Mol. Biol. 251:41-49(1995) [PubMed] [Europe PMC] [Abstract]
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- "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
- "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]