≡

Potassium Inwardly Rectifying Channel Subfamily J, Member 6 (KCNJ6)

[Edit]

Kir3.2; GIRK2; KATP2; BIR1; hiGIRK2; KCNJ7; G protein-activated inward rectifier potassium channel 2; Inward rectifier K(+) channel Kir3.2

Potassium Inwardly Rectifying Channel Subfamily J, Member 6 (KCNJ6)
CCC P922
HGNC 6267
MGI 104781
PubMed 20220551
RGD 2959
UniProt P48051
Wiki KCNJ6
ATP-sensitive potassium channels, also called K(ATP) channels, are closed by an increase in the intracellular ATP concentration of the cell and thereby provide a means of linking cellular metabolism to the electrical excitability of the plasma membrane. Sakura et al. (1995) cloned the KCNJ6 gene, which encodes a putative subunit of a human ATP-sensitive K-channel expressed in brain and beta cells, and characterized its exon/intron structure. By screening of a somatic cell mapping panel and fluorescence in situ hybridization, they placed the gene on 21q22.1-q22.2. Analysis of SSCPs revealed the presence of 2 silent polymorphisms (pro149: CCG-CCA and asp328: GAC-GAT) with similar frequencies in normal and noninsulin-dependent diabetic patients.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Potassium Inwardly Rectifying Channel Subfamily J, Member 6 (KCNJ6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Potassium Inwardly Rectifying Channel Subfamily J, Member 6 (KCNJ6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Potassium Inwardly Rectifying Channel Subfamily J, Member 6 (KCNJ6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Potassium Inwardly Rectifying Channel Subfamily J, Member 6 (KCNJ6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Potassium Inwardly Rectifying Channel Subfamily J, Member 6 (KCNJ6) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Potassium Inwardly Rectifying Channel Subfamily J, Member 6 (KCNJ6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Potassium Inwardly Rectifying Channel Subfamily J, Member 6 (KCNJ6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Potassium Inwardly Rectifying Channel Subfamily J, Member 6 (KCNJ6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Potassium Inwardly Rectifying Channel Subfamily J, Member 6 (KCNJ6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Potassium Inwardly Rectifying Channel Subfamily J, Member 6 (KCNJ6) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Potassium Inwardly Rectifying Channel Subfamily J, Member 6 (KCNJ6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Potassium Inwardly Rectifying Channel Subfamily J, Member 6 (KCNJ6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Potassium Inwardly Rectifying Channel Subfamily J, Member 6 (KCNJ6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Potassium Inwardly Rectifying Channel Subfamily J, Member 6 (KCNJ6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Potassium Inwardly Rectifying Channel Subfamily J, Member 6 (KCNJ6) ELISA Kit Customized Service Offer
  1. "Pancreatic islet cells express a family of inwardly rectifying K+ channel subunits which interact to form G-protein-activated channels."J. Biol. Chem. 270:26086-26091(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Co-expression of human Kir3 subunits can yield channels with different functional properties."Cell. Signal. 11:871-883(1999) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Characterization and variation of a human inwardly-rectifying-K-channel gene (KCNJ6): a putative ATP-sensitive K-channel subunit."FEBS Lett. 367:193-197(1995) [PubMed] [Europe PMC] [Abstract]
  5. "Isolation of a cDNA clone encoding a KATP channel-like protein expressed in insulin-secreting cells, localization of the human gene to chromosome band 21q22.1, and linkage studies with NIDDM."Diabetes 44:592-596(1995) [PubMed] [Europe PMC] [Abstract]