Potassium Voltage Gated Channel KQT Like Subfamily, Member 5 (KCNQ5)

KCNQ5 contains 6 transmembrane domains, with a pore domain between transmembrane segments S5 and S6. It has several potential sites for protein kinase C phosphorylation, but lacks the N-terminal site for cAMP-dependent phosphorylation that is present in KCNQ1 and KCNQ2.

KCNQ5 shares 65% amino acid identity with KCNQ4, 50% identity with KCNQ3 and KCNQ2, and 40% identity with KCNQ1, with greatest homology in the membrane-spanning region and the pore region. Northern blot analysis revealed a major 7.5-kb transcript in adult skeletal muscle and brain. Within brain, KCNQ5 showed strongest expression in cerebral cortex, occipital pole, frontal lobe, and temporal lobe. In contrast to KCNQ2, KCNQ5 expression was reduced or absent in cerebellum.