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KIN, Antigenic Determinant Of RecA Protein Homolog (KIN)

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KIN17; BTCD; Binding to curved DNA; DNA/RNA-binding protein KIN17

KIN, Antigenic Determinant Of RecA Protein Homolog (KIN)
CCC P904
HGNC 6327
MGI 96676
PubMed 1923796
RGD 1596107
UniProt O60870
Wiki KIN
KIN is a nuclear protein that forms intranuclear foci during proliferation and is redistributed in the nucleoplasm during the cell cycle. Short-wave ultraviolet light provokes the relocalization of the protein, suggesting its participation in the cellular response to DNA damage. Originally selected based on protein-binding with RecA antibodies, the mouse protein presents a limited similarity with a functional domain of the bacterial RecA protein, a characteristic shared by this human ortholog.
KIN17 mRNA was ubiquitously expressed, with particularly high levels of expression in muscle, heart, and testis. KIN17 protein is concentrated in intranuclear focal structures in proliferating cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant KIN, Antigenic Determinant Of RecA Protein Homolog (KIN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to KIN, Antigenic Determinant Of RecA Protein Homolog (KIN) Monoclonal Antibody Customized Service Offer
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Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant KIN, Antigenic Determinant Of RecA Protein Homolog (KIN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to KIN, Antigenic Determinant Of RecA Protein Homolog (KIN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to KIN, Antigenic Determinant Of RecA Protein Homolog (KIN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for KIN, Antigenic Determinant Of RecA Protein Homolog (KIN) CLIA Kit Customized Service Offer
n/a ELISA Kit for KIN, Antigenic Determinant Of RecA Protein Homolog (KIN) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant KIN, Antigenic Determinant Of RecA Protein Homolog (KIN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to KIN, Antigenic Determinant Of RecA Protein Homolog (KIN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to KIN, Antigenic Determinant Of RecA Protein Homolog (KIN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for KIN, Antigenic Determinant Of RecA Protein Homolog (KIN) CLIA Kit Customized Service Offer
n/a ELISA Kit for KIN, Antigenic Determinant Of RecA Protein Homolog (KIN) ELISA Kit Customized Service Offer
  1. "Molecular cloning and characterization of the human KIN17 cDNA encoding a component of the UVC response that is conserved among metazoans."Carcinogenesis 21:1701-1710(2000) [PubMed] [Europe PMC] [Abstract].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract].
  5. "A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity."PLoS Genet. 9:E1003210-E1003210(2013) [PubMed] [Europe PMC] [Abstract]
  6. "Differential expression of the HsKin17 protein during differentiation of in vitro reconstructed human skin."Arch. Dermatol. Res. 289:448-456(1997) [PubMed] [Europe PMC] [Abstract]
  7. "Human kin17 protein directly interacts with the simian virus 40 large T antigen and inhibits DNA replication."Cancer Res. 62:5425-5435(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Ionizing radiation triggers chromatin-bound kin17 complex formation in human cells."J. Biol. Chem. 277:19156-19165(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Participation of kin17 protein in replication factories and in other DNA transactions mediated by high molecular weight nuclear complexes."Mol. Cancer Res. 1:519-531(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Selective interactions of human kin17 and RPA proteins with chromatin and the nuclear matrix in a DNA damage- and cell cycle-regulated manner."Nucleic Acids Res. 31:4162-4175(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Global genome repair is required to activate KIN17, a UVC-responsive gene involved in DNA replication."Proc. Natl. Acad. Sci. U.S.A. 100:616-621(2003) [PubMed] [Europe PMC] [Abstract]
  12. "The human stress-activated protein kin17 belongs to the multiprotein DNA replication complex and associates in vivo with mammalian replication origins."Mol. Cell. Biol. 25:3814-3830(2005) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  15. "A tandem of SH3-like domains participates in RNA binding in KIN17, a human protein activated in response to genotoxics."J. Mol. Biol. 364:764-776(2006) [PubMed] [Europe PMC] [Abstract]
  16. "Solution structure of the region 51-160 of human KIN17 reveals an atypical winged helix domain."Protein Sci. 16:2750-2755(2007) [PubMed] [Europe PMC] [Abstract]