Keratin 32 (KRT32)

The predicted protein has 405 amino acids, including a 41-amino acid C terminus. The amino acid sequences of the human and mouse HA2 proteins are 81% identical. Northern blot analysis detected HA2 transcripts in human scalp but not unhaired breast epidermis.The HA2 gene and its flanking sequences span over 14 kb. The gene contains 7 exons; the 6 conserved introns are located in the region encoding the alpha-helical domain. The 5-prime flanking sequence contains a LEF1-binding site, which is present in several hair follicle-associated genes.One subcluster, group A, consists of KRTHA1, KRTHA3A, KRTHA3B, and KRTHA4, which share 89% overall amino acid identity. A second subcluster, group B, contains KRTHA7 and KRTHA8, as well as the hair keratin pseudogene, which the authors called HAA.