Keratin 33B (KRT33B)

KRT33B is a member of the keratin gene family. It is one of the type I hair keratin genes which are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. the deduced KRTHA3B protein has 405 amino acids and shares 93.3% amino acid sequence identity with KRTHA3A.KRTHA3B is expressed in the human hair follicle. HA3I and HA3II are distinct, single-copy genes.

The cDNA has an open reading frame that encodes 362 amino acids, including a predicted 37-amino acid C-terminal domain; the authors estimated that the cDNA lacks the coding sequence for 43 N-terminal residues. The partial HA3II isoform differs from the HA3I isoform (KRTHA3A) by 24 amino acids, 8 of which are in the center of the C-terminal domain.