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Male Specific Lethal 3 Homolog (MSL3)

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MSL3L1; Male-specific lethal-3 protein-like 1

Male Specific Lethal 3 Homolog (MSL3)
CCC P866
HGNC 7370
MGI 1341851
PubMed 16401419
RGD 1549763
UniProt Q8N5Y2
MSL3 encodes a nuclear protein that is similar to the product of the Drosophila male-specific lethal-3 gene. The Drosophila protein plays a critical role in a dosage-compensation pathway, which equalizes X-linked gene expression in males and females. Thus, the human protein is thought to play a similar function in chromatin remodeling and transcriptional regulation, and it has been found as part of a complex that is responsible for histone H4 lysine-16 acetylation. This gene can undergo X inactivation. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 7 and 8. The deduced 521-amino acid MSL3L1 protein shares 30% overall sequence identity with Drosophila MSL3 and 86% identity with mouse Msl3l1, which the authors also identified.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Male Specific Lethal 3 Homolog (MSL3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Male Specific Lethal 3 Homolog (MSL3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Male Specific Lethal 3 Homolog (MSL3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Male Specific Lethal 3 Homolog (MSL3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Male Specific Lethal 3 Homolog (MSL3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Male Specific Lethal 3 Homolog (MSL3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Male Specific Lethal 3 Homolog (MSL3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Male Specific Lethal 3 Homolog (MSL3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Male Specific Lethal 3 Homolog (MSL3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Male Specific Lethal 3 Homolog (MSL3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Male Specific Lethal 3 Homolog (MSL3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Male Specific Lethal 3 Homolog (MSL3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Male Specific Lethal 3 Homolog (MSL3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Male Specific Lethal 3 Homolog (MSL3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Male Specific Lethal 3 Homolog (MSL3) ELISA Kit Customized Service Offer
  1. "Characterization of a novel chromo domain gene in Xp22.3 with homology to Drosophila msl-3."Genomics 59:77-84(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16."Mol. Cell. Biol. 25:9175-9188(2005) [PubMed] [Europe PMC] [Abstract]
  7. ErratumMol. Cell. Biol. 26:387-387(2006)
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex."J. Biol. Chem. 285:4268-4272(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Structural insight into the regulation of MOF in the male-specific lethal complex and the non-specific lethal complex."Cell Res. 22:1078-1081(2012) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  15. "Corecognition of DNA and a methylated histone tail by the MSL3 chromodomain."Nat. Struct. Mol. Biol. 17:1027-1029(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Structural and biochemical studies on the chromo-barrel domain of male specific lethal 3 (MSL3) reveal a binding preference for mono- or dimethyllysine 20 on histone H4."J. Biol. Chem. 285:40879-40890(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Structural basis for MOF and MSL3 recruitment into the dosage compensation complex by MSL1."Nat. Struct. Mol. Biol. 18:142-149(2011) [PubMed] [Europe PMC] [Abstract]