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Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Inhibitor Like Protein 1 (NFkBIL1)

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IKBL; NFKBIL; Inhibitor of kappa B-like protein; NF-kappa-B inhibitor-like protein 1

Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Inhibitor Like Protein 1 (NFkBIL1)
CCC P840
HGNC 7800
MGI 1340031
PubMed 17544510
RGD 1303310
UniProt Q9UBC1
Wiki NFKBIL1

A cDNA was isolated from a U937 premonocytic leukemia cell line library and was predicted to code for a 381-amino acid protein. The protein contains ankyrin motifs similar to those of the I-kappa-B family of proteins. NFkBIL1 spans 13.5 kb of genomic DNA and its 3-prime end is about 12 kb from the 5-prime end of TNFB. Northern blot analysis detected a 1.6-kb mRNA in several cell types, including monocytes, T cells, B cells, and hepatocytes.Phosphorylation of serine residues on the I-kappa-B proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
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Antibodies n/a Monoclonal Antibody to Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Inhibitor Like Protein 1 (NFkBIL1) Monoclonal Antibody Customized Service Offer
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Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Inhibitor Like Protein 1 (NFkBIL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Inhibitor Like Protein 1 (NFkBIL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Inhibitor Like Protein 1 (NFkBIL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Inhibitor Like Protein 1 (NFkBIL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Inhibitor Like Protein 1 (NFkBIL1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Inhibitor Like Protein 1 (NFkBIL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Inhibitor Like Protein 1 (NFkBIL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Inhibitor Like Protein 1 (NFkBIL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Inhibitor Like Protein 1 (NFkBIL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Inhibitor Like Protein 1 (NFkBIL1) ELISA Kit Customized Service Offer
  1. "Characterization of a novel gene in the human major histocompatibility complex that encodes a potential new member of the I kappa B family of proteins."Hum. Mol. Genet. 3:793-799(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Nucleotide sequencing analysis of the 146-kilobase segment around the IkBL and MICA genes at the centromeric end of the HLA class I region."Genomics 47:372-382(1998) [PubMed] [Europe PMC] [Abstract]
  3. "The central MHC gene IKBL carries a structural polymorphism that is associated with HLA-A3,B7,DR15."Immunogenetics 49:660-665(1999) [PubMed] [Europe PMC] [Abstract]
  4. "A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC."J. Immunol. 162:4745-4754(1999) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Cactin targets the MHC class III protein IkappaB-like (IkappaBL) and inhibits NF-kappaB and interferon-regulatory factor signaling pathways."J. Biol. Chem. 285:36804-36817(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Identification of I kappa BL as the second major histocompatibility complex-linked susceptibility locus for rheumatoid arthritis."Am. J. Hum. Genet. 72:303-312(2003) [PubMed] [Europe PMC] [Abstract]