≡

Protein Kinase, Interferon Inducible Double Stranded RNA Dependent Inhibitor, Repressor Of (PRKRIR)

[Edit]

P52rIPK; DAP4; THAP0; P58 Repressor; 52 kDa repressor of the inhibitor of the protein kinase; Death-associated protein 4; THAP domain-containing protein 0

Protein Kinase, Interferon Inducible Double Stranded RNA Dependent Inhibitor, Repressor Of (PRKRIR)
CCC P786
HGNC 9440
MGI 1920231
PubMed 21910972
RGD 1309679
UniProt O43422
Wiki PRKRIR
PRKRIR contains a region (amino acids 86 to 200) of limited homology (24% identity) to the charged domain of HSP90.The THAP domain of the deduced 761-amino acid THAP0 protein includes a C2CH signature, an AVPTIF box, and several other conserved amino acids.
When coexpressed with PKR in yeast, P58(IPK) repressed PKR-mediated EIF2-alpha phosphorylation, inhibiting the normally toxic and growth-suppressive effects associated with PKR function. Conversely, introduction of P52(rIPK) into these strains resulted in restoration of both PKR activity and EIF2-alpha phosphorylation, concomitant with growth suppression due to inhibition of P58(IPK) function.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Kinase, Interferon Inducible Double Stranded RNA Dependent Inhibitor, Repressor Of (PRKRIR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Kinase, Interferon Inducible Double Stranded RNA Dependent Inhibitor, Repressor Of (PRKRIR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Kinase, Interferon Inducible Double Stranded RNA Dependent Inhibitor, Repressor Of (PRKRIR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Kinase, Interferon Inducible Double Stranded RNA Dependent Inhibitor, Repressor Of (PRKRIR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Kinase, Interferon Inducible Double Stranded RNA Dependent Inhibitor, Repressor Of (PRKRIR) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Kinase, Interferon Inducible Double Stranded RNA Dependent Inhibitor, Repressor Of (PRKRIR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Kinase, Interferon Inducible Double Stranded RNA Dependent Inhibitor, Repressor Of (PRKRIR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Kinase, Interferon Inducible Double Stranded RNA Dependent Inhibitor, Repressor Of (PRKRIR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Kinase, Interferon Inducible Double Stranded RNA Dependent Inhibitor, Repressor Of (PRKRIR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Kinase, Interferon Inducible Double Stranded RNA Dependent Inhibitor, Repressor Of (PRKRIR) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Kinase, Interferon Inducible Double Stranded RNA Dependent Inhibitor, Repressor Of (PRKRIR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Kinase, Interferon Inducible Double Stranded RNA Dependent Inhibitor, Repressor Of (PRKRIR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Kinase, Interferon Inducible Double Stranded RNA Dependent Inhibitor, Repressor Of (PRKRIR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Kinase, Interferon Inducible Double Stranded RNA Dependent Inhibitor, Repressor Of (PRKRIR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Kinase, Interferon Inducible Double Stranded RNA Dependent Inhibitor, Repressor Of (PRKRIR) ELISA Kit Customized Service Offer
  1. "Regulation of interferon-induced protein kinase PKR: modulation of P58IPK inhibitory function by a novel protein, P52rIPK."Mol. Cell. Biol. 18:859-871(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  6. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]