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RAB13, Member RAS Oncogene Family (RAB13)

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GIG4; Cell growth-inhibiting gene 4 protein; Ras-related protein Rab-13

RAB13, Member RAS Oncogene Family (RAB13)
CCC P771
HGNC 9762
MGI 1927232
PubMed 20008558
RGD 620880
UniProt P51153
Wiki RAB13
The predicted 203-amino acid protein has the typical structural features of Ras-related proteins, including a conserved GTP-binding site. RAB13 displays 61% and 56% amino acid identity with the human RAB8 and yeast Sec4 proteins, respectively. These proteins share a long conserved N-terminal region but have divergent C-terminal portions. Northern blot analysis showed that RAB13 is expressed as a 1.2-kb transcript in Caco-2 cells. Immunoblot analysis using antibodies against RAB13 detected a 24-kD protein in Caco-2 cell lysates. Immunofluorescence studies demonstrated that RAB13 colocalizes with the tight junction marker ZO1 (TJP1) in epithelial cells. In cells devoid of tight junctions, RAB13 associates with vesicles dispersed throughout the cytoplasm.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAB13, Member RAS Oncogene Family (RAB13) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAB13, Member RAS Oncogene Family (RAB13) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAB13, Member RAS Oncogene Family (RAB13) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAB13, Member RAS Oncogene Family (RAB13) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAB13, Member RAS Oncogene Family (RAB13) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAB13, Member RAS Oncogene Family (RAB13) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAB13, Member RAS Oncogene Family (RAB13) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAB13, Member RAS Oncogene Family (RAB13) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAB13, Member RAS Oncogene Family (RAB13) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAB13, Member RAS Oncogene Family (RAB13) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAB13, Member RAS Oncogene Family (RAB13) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAB13, Member RAS Oncogene Family (RAB13) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAB13, Member RAS Oncogene Family (RAB13) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAB13, Member RAS Oncogene Family (RAB13) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAB13, Member RAS Oncogene Family (RAB13) ELISA Kit Customized Service Offer
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  7. "The small GTPase Rab13 regulates assembly of functional tight junctions in epithelial cells."Mol. Biol. Cell 13:1819-1831(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Rab13 regulates PKA signaling during tight junction assembly."J. Cell Biol. 165:175-180(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Rab13 mediates the continuous endocytic recycling of occludin to the cell surface."J. Biol. Chem. 280:2220-2228(2005) [PubMed] [Europe PMC] [Abstract]
  10. "JRAB/MICAL-L2 is a junctional Rab13-binding protein mediating the endocytic recycling of occludin."Mol. Biol. Cell 17:2465-2475(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Rab13 regulates membrane trafficking between TGN and recycling endosomes in polarized epithelial cells."J. Cell Biol. 182:845-853(2008) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors."J. Cell Biol. 191:367-381(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Rab13 regulates neurite outgrowth in PC12 cells through its effector protein, JRAB/MICAL-L2."Mol. Cell. Biol. 30:1077-1087(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  17. "MICAL-like1 mediates epidermal growth factor receptor endocytosis."Mol. Biol. Cell 22:3431-3441(2011) [PubMed] [Europe PMC] [Abstract]
  18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  19. "Rab13 is upregulated during osteoclast differentiation and associates with small vesicles revealing polarized distribution in resorbing cells."J. Histochem. Cytochem. 60:537-549(2012) [PubMed] [Europe PMC] [Abstract]