≡

RAB27A, Member RAS Oncogene Family (RAB27A)

[Edit]

RAB27; RAM; GS2; Ras-related protein Rab-27A; GTP-binding protein Ram

RAB27A, Member RAS Oncogene Family (RAB27A)
CCC P769
HGNC 9766
MGI 1861441
PubMed 11228153
RGD 620918
UniProt P51159
Wiki RAB27A
RAB27A belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Mutations in this gene are associated with Griscelli syndrome type 2. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. The predicted 221-amino acid RAB27A human protein shares 96% identity with rat Ram. Sequence comparisons revealed that RAB27A and RAB27B are 71% identical and comprise a Rab subfamily. Northern blot analysis indicated that RAB27A was expressed as 1.3-, 2.7-, and 3.7-kb mRNAs in most human tissues and cell lines examined. Recombinant RAB27A and RAB27B exhibited GTP-binding activity in vitro.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAB27A, Member RAS Oncogene Family (RAB27A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAB27A, Member RAS Oncogene Family (RAB27A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAB27A, Member RAS Oncogene Family (RAB27A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAB27A, Member RAS Oncogene Family (RAB27A) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAB27A, Member RAS Oncogene Family (RAB27A) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAB27A, Member RAS Oncogene Family (RAB27A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAB27A, Member RAS Oncogene Family (RAB27A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAB27A, Member RAS Oncogene Family (RAB27A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAB27A, Member RAS Oncogene Family (RAB27A) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAB27A, Member RAS Oncogene Family (RAB27A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAB27A, Member RAS Oncogene Family (RAB27A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAB27A, Member RAS Oncogene Family (RAB27A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAB27A, Member RAS Oncogene Family (RAB27A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAB27A, Member RAS Oncogene Family (RAB27A) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAB27A, Member RAS Oncogene Family (RAB27A) ELISA Kit Customized Service Offer
  1. "Deficient geranylgeranylation of Ram/Rab27 in choroideremia."J. Biol. Chem. 270:24420-24427(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning and characterization of rab27a and rab27b, novel human rab proteins shared by melanocytes and platelets."Biochem. Mol. Med. 60:27-37(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning, mapping and characterization of the human RAB27A gene."Gene 239:109-116(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Melanophilin directly links Rab27a and myosin Va through its distinct coiled-coil regions."FEBS Lett. 517:233-238(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Proteomic analysis of early melanosomes: identification of novel melanosomal proteins."J. Proteome Res. 2:69-79(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Munc13-4 is an effector of rab27a and controls secretion of lysosomes in hematopoietic cells."Mol. Biol. Cell 16:731-741(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes."J. Proteome Res. 5:3135-3144(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Secretory cytotoxic granule maturation and exocytosis require the effector protein hMunc13-4."Nat. Immunol. 8:257-267(2007) [PubMed] [Europe PMC] [Abstract]
  11. "A newly identified isoform of Slp2a associates with Rab27a in cytotoxic T cells and participates in cytotoxic granule secretion."Blood 112:5052-5062(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  14. "Mutations in RAB27A cause Griscelli syndrome associated with haemophagocytic syndrome."Nat. Genet. 25:173-176(2000) [PubMed] [Europe PMC] [Abstract]
  15. "Evidence that Griscelli syndrome with neurological involvement is caused by mutations in RAB27A, not MYO5A."Am. J. Hum. Genet. 71:407-414(2002) [PubMed] [Europe PMC] [Abstract]
  16. ErratumAm. J. Hum. Genet. 71:1007-1007(2002)
  17. "Biochemical and functional characterization of Rab27a mutations occurring in Griscelli syndrome patients."Blood 101:2736-2742(2003) [PubMed] [Europe PMC] [Abstract]
  18. "Characterization of the molecular defects in Rab27a, caused by RAB27A missense mutations found in patients with Griscelli syndrome."J. Biol. Chem. 278:11386-11392(2003) [PubMed] [Europe PMC] [Abstract]