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RAD23 Homolog B (RAD23B)

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HHR23B; P58; HR23B; XP-C Repair Complementing Protein; XP-C Repair Complementing Complex 58 kDa; UV excision repair protein RAD23 homolog B

RAD23 Homolog B (RAD23B)
CCC P751
HGNC 9813
MGI 105128
PubMed 23776089
RGD 1562958
UniProt P54727
Wiki RAD23B
RAD23B is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in the nucleotide excision repair (NER). This protein was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro.
This protein was also shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic pathway in cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP751Hu01 Recombinant RAD23 Homolog B (RAD23B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAP751Hu01 Polyclonal Antibody to RAD23 Homolog B (RAD23B) WB; IHC; ICC; IP.
MAP751Hu21 Monoclonal Antibody to RAD23 Homolog B (RAD23B) WB; IHC; ICC; IP.
Assay Kits SEP751Hu ELISA Kit for RAD23 Homolog B (RAD23B) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAD23 Homolog B (RAD23B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAD23 Homolog B (RAD23B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAD23 Homolog B (RAD23B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAD23 Homolog B (RAD23B) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAD23 Homolog B (RAD23B) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAD23 Homolog B (RAD23B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAD23 Homolog B (RAD23B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAD23 Homolog B (RAD23B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAD23 Homolog B (RAD23B) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAD23 Homolog B (RAD23B) ELISA Kit Customized Service Offer
  1. "Purification and cloning of a nucleotide excision repair complex involving the Xeroderma pigmentosum group C protein and a human homologue of yeast RAD23."EMBO J. 13:1831-1843(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Expression of a novel RAD23B mRNA splice variant in the human testis."J. Androl. 25:363-368(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Two human homologs of Rad23 are functionally interchangeable in complex formation and stimulation of XPC repair activity."Mol. Cell. Biol. 17:6924-6931(1997) [PubMed] [Europe PMC] [Abstract]
  7. "Xeroderma pigmentosum group C protein complex is the initiator of global genome nucleotide excision repair."Mol. Cell 2:223-232(1998) [PubMed] [Europe PMC] [Abstract]
  8. "Interaction of hHR23 with S5a. The ubiquitin-like domain of hHR23 mediates interaction with S5a subunit of 26 S proteasome."J. Biol. Chem. 274:28019-28025(1999) [PubMed] [Europe PMC] [Abstract]
  9. "Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B."Hum. Mol. Genet. 9:1795-1803(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Stable binding of human XPC complex to irradiated DNA confers strong discrimination for damaged sites."J. Mol. Biol. 300:275-290(2000) [PubMed] [Europe PMC] [Abstract]
  11. "Centrosome protein centrin 2/caltractin 1 is part of the xeroderma pigmentosum group C complex that initiates global genome nucleotide excision repair."J. Biol. Chem. 276:18665-18672(2001) [PubMed] [Europe PMC] [Abstract]
  12. "A molecular mechanism for DNA damage recognition by the xeroderma pigmentosum group C protein complex."DNA Repair 1:95-107(2002) [PubMed] [Europe PMC] [Abstract]
  13. "The carboxy-terminal domain of the XPC protein plays a crucial role in nucleotide excision repair through interactions with transcription factor IIH."DNA Repair 1:449-461(2002) [PubMed] [Europe PMC] [Abstract]
  14. "DNA bending by the human damage recognition complex XPC-HR23B."DNA Repair 2:325-336(2003) [PubMed] [Europe PMC] [Abstract]
  15. "A novel regulation mechanism of DNA repair by damage-induced and RAD23-dependent stabilization of xeroderma pigmentosum group C protein."Genes Dev. 17:1630-1645(2003) [PubMed] [Europe PMC] [Abstract]
  16. "A complex between peptide:N-glycanase and two proteasome-linked proteins suggests a mechanism for the degradation of misfolded glycoproteins."Proc. Natl. Acad. Sci. U.S.A. 101:13774-13779(2004) [PubMed] [Europe PMC] [Abstract]
  17. "Studies on the intracellular localization of hHR23B."Biochem. Biophys. Res. Commun. 337:1296-1300(2005) [PubMed] [Europe PMC] [Abstract]
  18. "Centrin 2 stimulates nucleotide excision repair by interacting with xeroderma pigmentosum group C protein."Mol. Cell. Biol. 25:5664-5674(2005) [PubMed] [Europe PMC] [Abstract]
  19. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  20. "Evidence for distinct functions for human DNA repair factors hHR23A and hHR23B."FEBS Lett. 580:3401-3408(2006) [PubMed] [Europe PMC] [Abstract]
  21. "Mass spectrometric characterization of the affinity-purified human 26S proteasome complex."Biochemistry 46:3553-3565(2007) [PubMed] [Europe PMC] [Abstract]
  22. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  23. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  24. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  25. "Variably modulated gating of the 26S proteasome by ATP and polyubiquitin."Biochem. J. 421:397-404(2009) [PubMed] [Europe PMC] [Abstract]
  26. "Two-step recognition of DNA damage for mammalian nucleotide excision repair: Directional binding of the XPC complex and DNA strand scanning."Mol. Cell 36:642-653(2009) [PubMed] [Europe PMC] [Abstract]
  27. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  28. "Photo-cross-linking of XPC-Rad23B to cisplatin-damaged DNA reveals contacts with both strands of the DNA duplex and spans the DNA adduct."Biochemistry 49:669-678(2010) [PubMed] [Europe PMC] [Abstract]
  29. "Stimulation of DNA glycosylase activities by XPC Protein Complex: Roles of protein-protein interactions."J. Nucleic Acids 2010:455-459(2010) [PubMed] [Europe PMC] [Abstract]
  30. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  31. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  32. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  33. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  34. "Binding surface mapping of intra- and interdomain interactions among hHR23B, ubiquitin, and polyubiquitin binding site 2 of S5a."J. Biol. Chem. 278:36621-36627(2003) [PubMed] [Europe PMC] [Abstract]
  35. "Structure of the ubiquitin-interacting motif of S5a bound to the ubiquitin-like domain of HR23B."J. Biol. Chem. 279:4760-4767(2004) [PubMed] [Europe PMC] [Abstract]
  36. "Solution structure and backbone dynamics of the XPC-binding domain of the human DNA repair protein hHR23B."FEBS J. 272:2467-2476(2005) [PubMed] [Europe PMC] [Abstract]