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RAD51 Homolog C (RAD51C)

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RAD51L2; R51H3; RAD51-like protein 2; DNA repair protein RAD51 homolog 3

RAD51 Homolog C (RAD51C)
CCC P749
HGNC 9820
MGI 2150020
PubMed 21990120
RGD 1563765
UniProt O43502
Wiki RAD51C
RAD51C is a member of the RAD51 family of related genes, which encode strand-transfer proteins thought to be involved in recombinational repair of damaged DNA and in meiotic recombination. This gene product interacts with two other DNA repair proteins, encoded by RAD51B and XRCC3, but not with itself. The protein copurifies with XRCC3 protein in a complex, reflecting their endogenous association and suggesting a cooperative role during recombinational repair. This gene is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breast tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor progression.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAD51 Homolog C (RAD51C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAD51 Homolog C (RAD51C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAD51 Homolog C (RAD51C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAD51 Homolog C (RAD51C) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAD51 Homolog C (RAD51C) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAD51 Homolog C (RAD51C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAD51 Homolog C (RAD51C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAD51 Homolog C (RAD51C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAD51 Homolog C (RAD51C) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAD51 Homolog C (RAD51C) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAD51 Homolog C (RAD51C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAD51 Homolog C (RAD51C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAD51 Homolog C (RAD51C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAD51 Homolog C (RAD51C) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAD51 Homolog C (RAD51C) ELISA Kit Customized Service Offer
  1. "Isolation and characterization of RAD51C, a new human member of the RAD51 family of related genes."Nucleic Acids Res. 26:1179-1184(1998) [PubMed] [Europe PMC] [Abstract]
  2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Identification and purification of two distinct complexes containing the five RAD51 paralogs."Genes Dev. 15:3296-3307(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Mediator function of the human Rad51B-Rad51C complex in Rad51/RPA-catalyzed DNA strand exchange."Genes Dev. 15:3308-3318(2001) [PubMed] [Europe PMC] [Abstract]
  6. "RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51."J. Biol. Chem. 277:8406-8411(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Interactions involving the Rad51 paralogs Rad51C and XRCC3 in human cells."Nucleic Acids Res. 30:1001-1008(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells."Nucleic Acids Res. 30:1009-1015(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Complex formation by the human Rad51B and Rad51C DNA repair proteins and their activities in vitro."J. Biol. Chem. 278:2469-2478(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Identification of functional domains in the RAD51L2 (RAD51C) protein and its requirement for gene conversion."J. Biol. Chem. 278:45445-45450(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Domain mapping of the Rad51 paralog protein complexes."Nucleic Acids Res. 32:169-178(2004) [PubMed] [Europe PMC] [Abstract]
  12. "RAD51C is required for Holliday junction processing in mammalian cells."Science 303:243-246(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Cellular localization of human Rad51C and regulation of ubiquitin-mediated proteolysis of Rad51."J. Cell. Biochem. 96:1095-1109(2005) [PubMed] [Europe PMC] [Abstract]
  14. "Interplay between human DNA repair proteins at a unique double-strand break in vivo."EMBO J. 25:222-231(2006) [PubMed] [Europe PMC] [Abstract]
  15. "Cellular redistribution of Rad51 in response to DNA damage: novel role for Rad51C."J. Biol. Chem. 284:31945-31952(2009) [PubMed] [Europe PMC] [Abstract]
  16. "RAD51C facilitates checkpoint signaling by promoting CHK2 phosphorylation."J. Cell Biol. 185:587-600(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Discovery of a novel function for human Rad51: maintenance of the mitochondrial genome."J. Biol. Chem. 285:18984-18990(2010) [PubMed] [Europe PMC] [Abstract]
  18. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  19. "hSWS1.SWSAP1 is an evolutionarily conserved complex required for efficient homologous recombination repair."J. Biol. Chem. 286:41758-41766(2011) [PubMed] [Europe PMC] [Abstract]
  20. "The RAD51 paralogs ensure cellular protection against mitotic defects and aneuploidy."J. Cell Sci. 126:348-359(2013) [PubMed] [Europe PMC] [Abstract]
  21. "Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway."Mol. Cell. Biol. 33:387-395(2013) [PubMed] [Europe PMC] [Abstract]
  22. "Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair."Oncogene 33:4803-4812(2014) [PubMed] [Europe PMC] [Abstract]
  23. "Ring-shaped Rad51 paralog protein complexes bind Holliday junctions and replication forks as visualized by electron microscopy."J. Biol. Chem. 285:13349-13356(2010) [PubMed] [Europe PMC] [Abstract]
  24. "Mutation of the RAD51C gene in a Fanconi anemia-like disorder."Nat. Genet. 42:406-409(2010) [PubMed] [Europe PMC] [Abstract]
  25. "Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene." Nat. Genet. 42:410-414(2010) [PubMed] [Europe PMC] [Abstract]
  26. "Analysis of RAD51C germline mutations in high-risk breast and ovarian cancer families and ovarian cancer patients."Hum. Mutat. 33:95-99(2012) [PubMed] [Europe PMC] [Abstract]