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RAD52 Homolog (RAD52)

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DNA repair protein RAD52 homolog

RAD52 Homolog (RAD52)
CCC P747
HGNC 9824
MGI 101949
PubMed 23357952
RGD 1304975
UniProt P43351
Wiki RAD52
RAD52 shares similarity with Saccharomyces cerevisiae Rad52, a protein important for DNA double-strand break repair and homologous recombination. This gene product was shown to bind single-stranded DNA ends, and mediate the DNA-DNA interaction necessary for the annealing of complementary DNA strands. It was also found to interact with DNA recombination protein RAD51, which suggested its role in RAD51 related DNA recombination and repair.The RAD52 epistasis group, which is mainly responsible for DNA double-strand break repair, contains 8 genes: RAD50 through RAD57. One of these, RAD51, has been cloned and found to have homology in yeast, chicken, mouse, and human to the bacterial Rec-A (RECA) protein, which is required for homologous recombination.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAD52 Homolog (RAD52) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAD52 Homolog (RAD52) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAD52 Homolog (RAD52) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAD52 Homolog (RAD52) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAD52 Homolog (RAD52) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAD52 Homolog (RAD52) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAD52 Homolog (RAD52) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAD52 Homolog (RAD52) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAD52 Homolog (RAD52) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAD52 Homolog (RAD52) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAD52 Homolog (RAD52) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAD52 Homolog (RAD52) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAD52 Homolog (RAD52) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAD52 Homolog (RAD52) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAD52 Homolog (RAD52) ELISA Kit Customized Service Offer
  1. "The human and mouse homologs of the yeast RAD52 gene: cDNA cloning, sequence analysis, assignment to human chromosome 12p12.2-p13, and mRNA expression in mouse tissues."Genomics 25:199-206(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning of human and mouse genes homologous to RAD52, a yeast gene involved in DNA repair and recombination."Mutat. Res. 315:295-305(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Expression of human RAD52 confers resistance to ionizing radiation in mammalian cells."J. Biol. Chem. 270:15467-15470(1995) [PubMed] [Europe PMC] [Abstract]
  4. "Identification of novel isoforms of human RAD52."Biochim. Biophys. Acta 1489:303-314(1999) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Physical interaction between human RAD52 and RPA is required for homologous recombination in mammalian cells."J. Biol. Chem. 271:18996-19000(1996) [PubMed] [Europe PMC] [Abstract]
  8. "Regulation of ionizing radiation-induced Rad52 nuclear foci formation by c-Abl-mediated phosphorylation."J. Biol. Chem. 277:48944-48948(2002) [PubMed] [Europe PMC] [Abstract]
  9. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Crystal structure of the homologous-pairing domain from the human Rad52 recombinase in the undecameric form."Mol. Cell 10:359-371(2002) [PubMed] [Europe PMC] [Abstract]
  12. "Structure of the single-strand annealing domain of human RAD52 protein."Proc. Natl. Acad. Sci. U.S.A. 99:13492-13497(2002) [PubMed] [Europe PMC] [Abstract]