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RAD54 Like Protein (RAD54L)

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hHR54; hRAD54; RAD54A; DNA repair and recombination protein RAD54-like

RAD54 Like Protein (RAD54L)
CCC P746
HGNC 9826
MGI 894697
PubMed 16520463
UniProt Q92698
Wiki RAD54L
RAD54L belongs to the DEAD-like helicase superfamily, and shares similarity with Saccharomyces cerevisiae Rad54, a protein known to be involved in the homologous recombination and repair of DNA. RAD54 protein dissociates RAD51 from nucleoprotein filaments formed on double-stranded DNA (dsDNA). Addition of RAD54 protein overcame inhibition of DNA strand exchange by RAD51 protein bound to substrate dsDNA. Species preference in the RAD51 dissociation and DNA strand exchange assays underlined the importance of specific RAD54-RAD51 protein interactions. RAD51 protein was unable to release dsDNA upon ATP hydrolysis, leaving it stuck on the heteroduplex DNA product after DNA strand exchange. The authors suggested that RAD54 protein is involved in the turnover of RAD51-dsDNA filaments.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAD54 Like Protein (RAD54L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAD54 Like Protein (RAD54L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAD54 Like Protein (RAD54L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAD54 Like Protein (RAD54L) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAD54 Like Protein (RAD54L) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAD54 Like Protein (RAD54L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAD54 Like Protein (RAD54L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAD54 Like Protein (RAD54L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAD54 Like Protein (RAD54L) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAD54 Like Protein (RAD54L) ELISA Kit Customized Service Offer
  1. "Human and mouse homologs of the Saccharomyces cerevisiae RAD54 DNA repair gene: evidence for functional conservation."Curr. Biol. 6:828-838(1996) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Characterization of the human homologue of RAD54: a gene located on chromosome 1p32 at a region of high loss of heterozygosity in breast tumors."Cancer Res. 57:2378-2383(1997) [PubMed] [Europe PMC] [Abstract]
  5. "Interaction of human recombination proteins Rad51 and Rad54."Nucleic Acids Res. 25:4106-4110(1997) [PubMed] [Europe PMC] [Abstract]
  6. "The human RAD54 recombinational DNA repair protein is a double-stranded DNA-dependent ATPase."J. Biol. Chem. 273:28292-28297(1998) [PubMed] [Europe PMC] [Abstract]
  7. "Analysis of the RAD54 gene on chromosome 1p as a potential tumor-suppressor gene in parathyroid adenomas."Int. J. Cancer 83:80-82(1999) [PubMed] [Europe PMC] [Abstract]
  8. "The architecture of the human Rad54-DNA complex provides evidence for protein translocation along DNA."Proc. Natl. Acad. Sci. U.S.A. 98:8454-8460(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Homologous DNA pairing by human recombination factors Rad51 and Rad54."J. Biol. Chem. 277:42790-42794(2002) [PubMed] [Europe PMC] [Abstract]
  10. "Mutations in the RAD54 recombination gene in primary cancers."Oncogene 18:3427-3430(1999) [PubMed] [Europe PMC] [Abstract]