≡

Tripartite Motif Containing Protein 27 (TRIM27)

[Edit]

RFP; RNF76; Ret Finger Protein; RING finger protein 76

Tripartite Motif Containing Protein 27 (TRIM27)
CCC P739
HGNC 9975
MGI 97904
PubMed 24392305
RGD 1310105
UniProt P14373
Wiki TRIM27
TRIM27 encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nuclear matrix. It interacts with the enhancer of polycomb protein and represses gene transcription. It is also thought to be involved in the differentiation of male germ cells. Fusion of the N-terminus of this protein with the truncated C-terminus of the RET gene product has been shown to result in production of the ret transforming protein.Yeast 2-hybrid assays revealed that the coiled-coil domain of RFP associated with the EPcA domain and the C-terminal region of EPC. Both proteins coprecipitated from lysates of human cells and mostly colocalized in the nucleus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tripartite Motif Containing Protein 27 (TRIM27) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tripartite Motif Containing Protein 27 (TRIM27) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tripartite Motif Containing Protein 27 (TRIM27) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tripartite Motif Containing Protein 27 (TRIM27) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tripartite Motif Containing Protein 27 (TRIM27) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tripartite Motif Containing Protein 27 (TRIM27) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tripartite Motif Containing Protein 27 (TRIM27) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tripartite Motif Containing Protein 27 (TRIM27) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tripartite Motif Containing Protein 27 (TRIM27) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tripartite Motif Containing Protein 27 (TRIM27) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tripartite Motif Containing Protein 27 (TRIM27) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tripartite Motif Containing Protein 27 (TRIM27) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tripartite Motif Containing Protein 27 (TRIM27) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tripartite Motif Containing Protein 27 (TRIM27) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tripartite Motif Containing Protein 27 (TRIM27) ELISA Kit Customized Service Offer
  1. "Developmentally regulated expression of a human 'finger'-containing gene encoded by the 5' half of the ret transforming gene."Mol. Cell. Biol. 8:1853-1856(1988) [PubMed] [Europe PMC] [Abstract]
  2. "The tripartite motif family identifies cell compartments."EMBO J. 20:2140-2151(2001) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "ret transforming gene encodes a fusion protein homologous to tyrosine kinases."Mol. Cell. Biol. 7:1378-1385(1987) [PubMed] [Europe PMC] [Abstract]
  6. "RFP is a DNA binding protein associated with the nuclear matrix."Nucleic Acids Res. 20:5305-5310(1992) [PubMed] [Europe PMC] [Abstract]
  7. "Involvement of the rfp tripartite motif in protein-protein interactions and subcellular distribution."J. Cell Sci. 110:1563-1571(1997) [PubMed] [Europe PMC] [Abstract]
  8. "Ret finger protein is a normal component of PML nuclear bodies and interacts directly with PML."J. Cell Sci. 111:1319-1329(1998) [PubMed] [Europe PMC] [Abstract]
  9. "Interaction between the Ret finger protein and the Int-6 gene product and co-localisation into nuclear bodies."J. Cell Sci. 112:3331-3342(1999) [PubMed] [Europe PMC] [Abstract]
  10. "RET finger protein is a transcriptional repressor and interacts with enhancer of polycomb that has dual transcriptional functions."J. Biol. Chem. 275:39411-39419(2000) [PubMed] [Europe PMC] [Abstract]
  11. "Differential expression of RET finger protein in testicular germ cell tumors."Pathol. Int. 52:623-627(2002) [PubMed] [Europe PMC] [Abstract]
  12. "The Ret finger protein induces apoptosis via its RING finger-B box-coiled-coil motif."J. Biol. Chem. 278:31902-31908(2003) [PubMed] [Europe PMC] [Abstract]
  13. "Mi-2 beta associates with BRG1 and RET finger protein at the distinct regions with transcriptional activating and repressing abilities."J. Biol. Chem. 278:51638-51645(2003) [PubMed] [Europe PMC] [Abstract]
  14. "Novel tumorigenic rearrangement, Delta rfp/ret, in a papillary thyroid carcinoma from externally irradiated patient."Mutat. Res. 527:81-90(2003) [PubMed] [Europe PMC] [Abstract]
  15. "Selective ablation of retinoblastoma protein function by the RET finger protein."Mol. Cell 18:213-224(2005) [PubMed] [Europe PMC] [Abstract]
  16. "MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases."Mol. Cell 39:963-974(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  18. "Tripartite motif containing protein 27 negatively regulates CD4 T cells by ubiquitinating and inhibiting the class II PI3K-C2beta."Proc. Natl. Acad. Sci. U.S.A. 108:20072-20077(2011) [PubMed] [Europe PMC] [Abstract]
  19. "Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination."Cell 152:1051-1064(2013) [PubMed] [Europe PMC] [Abstract]
  20. "Identification of TRIM27 as a novel degradation target of Herpes Simplex Virus 1 ICP0."J. Virol. 89:220-229(2015) [PubMed] [Europe PMC] [Abstract]