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Tripartite Motif Containing Protein 13 (TRIM13)

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RFP2; Leu5; RNF77; DLEU5; Ret Finger Protein 2; RING finger protein 77; Leukemia-associated protein 5; B-cell chronic lymphocytic leukemia tumor suppressor Leu5

Tripartite Motif Containing Protein 13 (TRIM13)
CCC P738
HGNC 9976
MGI 1913847
RGD 1307609
UniProt O60858
TRIM13 encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This gene is located on chromosome 13 within the minimal deletion region for B-cell chronic lymphocytic leukemia. Multiple alternatively spliced transcript variants have been found for this gene.
In addition to the bicistronic transcript, they identified 4 major monocistronic RFP2 transcripts, 3 major monocistronic DLTET transcripts, and transcripts lacking both ORFs. RT-PCR detected 4 major transcripts ranging from 1.7 to 7.5 kb in all human tissues examined. Bicistronic and monocistronic Rfp2 and Dltet transcripts were present in mouse.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tripartite Motif Containing Protein 13 (TRIM13) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tripartite Motif Containing Protein 13 (TRIM13) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tripartite Motif Containing Protein 13 (TRIM13) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tripartite Motif Containing Protein 13 (TRIM13) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tripartite Motif Containing Protein 13 (TRIM13) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tripartite Motif Containing Protein 13 (TRIM13) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tripartite Motif Containing Protein 13 (TRIM13) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tripartite Motif Containing Protein 13 (TRIM13) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tripartite Motif Containing Protein 13 (TRIM13) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tripartite Motif Containing Protein 13 (TRIM13) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tripartite Motif Containing Protein 13 (TRIM13) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tripartite Motif Containing Protein 13 (TRIM13) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tripartite Motif Containing Protein 13 (TRIM13) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tripartite Motif Containing Protein 13 (TRIM13) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tripartite Motif Containing Protein 13 (TRIM13) ELISA Kit Customized Service Offer
  1. "A cosmid and cDNA fine physical map of a human chromosome 13q14 region frequently lost in B-cell chronic lymphocytic leukemia and identification of a new putative tumor suppressor gene, Leu5." FEBS Lett. 426:266-270(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Nucleotide sequence, transcription map, and mutation analysis of the 13q14 chromosomal region deleted in B-cell chronic lymphocytic leukemia."Blood 97:2098-2104(2001) [PubMed] [Europe PMC] [Abstract]
  3. "The tripartite motif family identifies cell compartments."EMBO J. 20:2140-2151(2001) [PubMed] [Europe PMC] [Abstract]
  4. "RFP2, c13ORF1, and FAM10A4 are the most likely tumor suppressor gene candidates for B-cell chronic lymphocytic leukemia."Cancer Genet. Cytogenet. 146:48-57(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence and analysis of human chromosome 13." Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The RBCC gene RFP2 (Leu5) encodes a novel transmembrane E3 ubiquitin ligase involved in ERAD."Mol. Biol. Cell 18:1670-1682(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Ret finger protein 2 enhances ionizing radiation-induced apoptosis via degradation of AKT and MDM2."Eur. J. Cell Biol. 90:420-431(2011) [PubMed] [Europe PMC] [Abstract]
  10. "TRIM13 regulates ER stress induced autophagy and clonogenic ability of the cells."Biochim. Biophys. Acta 1823:316-326(2012) [PubMed] [Europe PMC] [Abstract]