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Ret Finger Protein Like Protein 1 (RFPL1)

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RNF78; RFPL1L; RING finger protein 78

Ret Finger Protein Like Protein 1 (RFPL1)
CCC P737
HGNC 9977
PubMed 18656177
UniProt O75677
The deduced 287-amino acid RFPL1 protein is 91 to 94% identical to RFPL2 and RFPL3. Exon 1 of RFPL1 encodes a putative RING-like motif, which is 29% identical to that of RFP, and exon 2 encodes a B30-2 domain, which is 41% identical to that of RFP.
Northern blot analysis revealed expression of a 1.5-kb RFPL1 transcript that was abundant in prostate and less abundant in adult brain, fetal liver, and fetal kidney. A 1.2-kb transcript strongly expressed in testis and a 6-kb transcript strongly expressed in adult and fetal brain appeared to represent RFPL3S and RFPL1S, respectively. Analysis of a family with Opitz syndrome and unrelated normal individuals resulted in the detection of a polymorphic protein-truncating allele of RFPL1 that was not associated with the OS phenotype.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ret Finger Protein Like Protein 1 (RFPL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ret Finger Protein Like Protein 1 (RFPL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ret Finger Protein Like Protein 1 (RFPL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ret Finger Protein Like Protein 1 (RFPL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ret Finger Protein Like Protein 1 (RFPL1) ELISA Kit Customized Service Offer
  1. "Duplications on human chromosome 22 reveal a novel Ret finger protein-like gene family with sense and endogenous antisense transcripts."Genome Res. 9:803-814(1999) [PubMed] [Europe PMC] [Abstract]
  2. "A genome annotation-driven approach to cloning the human ORFeome."Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]