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Tripartite Motif Containing Protein 39 (TRIM39)

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RNF23; TFP; Ring Finger Protein 23; Testis-abundant finger protein; E3 ubiquitin-protein ligase TRIM39

Tripartite Motif Containing Protein 39 (TRIM39)
CCC P727
HGNC 10065
MGI 1890659
PubMed 23213251
RGD 1303115
UniProt Q9HCM9
TRIM39 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The function of this protein has not been identified. This gene lies within the major histocompatibility complex class I region on chromosome 6. Alternate splicing results in two transcript variants encoding different isoforms.
The deduced 519-amino acid protein, 98% identical to the 489-amino acid mouse sequence, contains a RING finger B-box coiled-coil (RBCC) domain and a C-terminal B30.2 domain. Northern blot analysis revealed near ubiquitous expression of a 3.4-kb transcript, with strongest expression in testis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tripartite Motif Containing Protein 39 (TRIM39) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tripartite Motif Containing Protein 39 (TRIM39) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tripartite Motif Containing Protein 39 (TRIM39) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tripartite Motif Containing Protein 39 (TRIM39) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tripartite Motif Containing Protein 39 (TRIM39) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tripartite Motif Containing Protein 39 (TRIM39) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tripartite Motif Containing Protein 39 (TRIM39) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tripartite Motif Containing Protein 39 (TRIM39) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tripartite Motif Containing Protein 39 (TRIM39) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tripartite Motif Containing Protein 39 (TRIM39) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tripartite Motif Containing Protein 39 (TRIM39) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tripartite Motif Containing Protein 39 (TRIM39) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tripartite Motif Containing Protein 39 (TRIM39) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tripartite Motif Containing Protein 39 (TRIM39) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tripartite Motif Containing Protein 39 (TRIM39) ELISA Kit Customized Service Offer
  1. "Molecular cloning of testis-abundant finger protein/ring finger protein 23 (RNF23), a novel RING-B box-coiled coil-B30.2 protein on the class I region of the human MHC."Biochem. Biophys. Res. Commun. 276:45-51(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity." Genetics 173:1555-1570(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "TRIM39 is a MOAP-1-binding protein that stabilizes MOAP-1 through inhibition of its poly-ubiquitination process."Exp. Cell Res. 315:1313-1325(2009) [PubMed] [Europe PMC] [Abstract]
  7. "The Trim39 ubiquitin ligase inhibits APC/CCdh1-mediated degradation of the Bax activator MOAP-1."J. Cell Biol. 197:361-367(2012) [PubMed] [Europe PMC] [Abstract]
  8. "One sequence two fold ? correct fold of the ZF-B-box domain from human tripartite motif protein 39."Submitted (SEP-2006) to the PDB data bank