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SEC23 Homolog A (SEC23A)

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SEC23-related protein A; Protein transport protein Sec23A

SEC23 Homolog A (SEC23A)
CCC P701
HGNC 10701
MGI 1349635
PubMed 16980979
RGD 1309103
UniProt Q15436
Wiki SEC23A
SEC23Ais a member of the SEC23 subfamily of the SEC23/SEC24 family. It is part of a protein complex and found in the ribosome-free transitional face of the endoplasmic reticulum (ER) and associated vesicles. This protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The encoded protein is suggested to play a role in the ER-Golgi protein trafficking.The deduced 765-amino acid protein shares 47.3% identity with yeast Sec23 and 84.3% identity with human SEC23B. RNase protection assays detected variable levels of SEC23A in all human tissues and cell lines examined. Western blot analysis revealed an 85-kD SEC23A protein in HepG2 cells and in mouse and rat tissues. SEC23A partitioned equally between cytosol and membranes in HepG2 cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SEC23 Homolog A (SEC23A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SEC23 Homolog A (SEC23A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SEC23 Homolog A (SEC23A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SEC23 Homolog A (SEC23A) CLIA Kit Customized Service Offer
n/a ELISA Kit for SEC23 Homolog A (SEC23A) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SEC23 Homolog A (SEC23A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SEC23 Homolog A (SEC23A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SEC23 Homolog A (SEC23A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SEC23 Homolog A (SEC23A) CLIA Kit Customized Service Offer
n/a ELISA Kit for SEC23 Homolog A (SEC23A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SEC23 Homolog A (SEC23A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SEC23 Homolog A (SEC23A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SEC23 Homolog A (SEC23A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SEC23 Homolog A (SEC23A) CLIA Kit Customized Service Offer
n/a ELISA Kit for SEC23 Homolog A (SEC23A) ELISA Kit Customized Service Offer
  1. "Cloning and functional characterization of mammalian homologues of the COPII component Sec23."Mol. Biol. Cell 7:1535-1546(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Two mammalian Sec16 homologues have nonredundant functions in endoplasmic reticulum (ER) export and transitional ER organization."Mol. Biol. Cell 18:839-849(2007) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  9. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  11. "Solution structure of the ZF-SEC23_SEC24 from human SEC23A."Submitted (OCT-2007) to the PDB data bank
  12. "Cranio-lenticulo-sutural dysplasia is caused by a SEC23A mutation leading to abnormal endoplasmic-reticulum-to-Golgi trafficking."Nat. Genet. 38:1192-1197(2006) [PubMed] [Europe PMC] [Abstract]